134161-20-9

Upstream product

• 772-38-3 4-tert-Butylphenylacetylene 
• 100-52-7 benzaldehyde 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 

Downstream Products

• 1352958-10-1 (5-(4-tert-butylphenyl)pent-1-en-4-yne-1,1,3-triyl)tribenzene 
• 1005385-47-6 3-(4-(tert-butyl)phenyl)-1-phenylprop-2-yn-1-one 
• 883018-08-4 2-(4-(tert-butyl)phenyl)-5-methylbenzo[d]oxazole 

Relevant academic research and scientific papers

Synthesis of benzoxazoles via the copper-catalyzed hydroamination of alkynones with 2-aminophenols

We describe herein the synthetic method to benzoxazole derivatives via the copper-catalyzed hydroamination of alkynones with 2-aminophenols. The method produced a wide variety of functionalized benzoxazole derivatives in good yields. Preliminary mechanistic experiments revealed that the reaction would proceed through the copper-catalyzed hydroamination of alkynones and the sequential intramolecular cyclization of β-iminoketones/elimination of acetophenone promoted by the copper catalyst.

Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by a Sterically Highly Demanding Chiral-at-Rhodium Lewis Acid

The enantioselective catalytic alkynylation of aromatic aldehydes is reported using a sterically highly hindered bis-cyclometalated rhodium-based Lewis acid catalyst featuring the octahedral metal as the only stereogenic center. Yields of 58-98% with 79-9