134161-81-2Relevant academic research and scientific papers
Synthesis of Solution-Processable Donor-Acceptor Pyranone Dyads for White Organic Light-Emitting Devices
Sharma, Chandra P.,Gupta, Neeraj M.,Singh, Jagriti,Yadav, Rohit Ashok Kumar,Dubey, Deepak Kumar,Rawat, Kundan S.,Jha, Ajay K.,Jou, Jwo-Huei,Goel, Atul
, p. 7674 - 7684 (2019)
A series of donor-acceptor pyranones (3a-m, 4a-h) were synthesized using α-oxo-ketene-S,S-acetal as the synthon for their application as emissive materials for energy-saving organic light-emitting devices (OLEDs). Among them, five pyranones 3f, 3g, 3h, 3m
A novel synthesis of aryl tethered imidazo[4,5-b]pyrazin-2-ones through in situ ring construction and contraction
Pratap, Ramendra,Roy, Abhijeet Deb,Roy, Raja,Ram, Vishnu Ji
, p. 1281 - 1285 (2007)
An innovative synthesis of aryl tethered 1,3-dimethylimidazo[4,5-b]pyrazin-2-ones 4 and 6 has been delineated through base catalyzed ring transformation of 6-aryl-4-(piperidin-1-yl)-2H-pyran-2-one-3-carbonitriles 1 and methyl 6-aryl-4-methylsulfanyl-2H-py
Synthesis, spectral characterization and photophysical studies of tetrahydroquinolines
Kennedy, L. John,Singh, Fateh V.,Subashini, C.
, (2020/10/18)
A metal-free, ultrasound-assisted, fast synthesis of fluorescent N-Boc-protected 1,2,3,4–tetrahydroquinolines 9a-p is described through carbanion-induced ring transformation of 6-aryl-2H-pyran-2-ones 7 with tert?butyl 3-oxopiperidine-1-carboxylate 8 under
Design, synthesis, in vitro and in vivo biological evaluation of pyranone-piperazine analogs as potent antileishmanial agents
Mishra, Shachi,Parmar, Naveen,Chandrakar, Pragya,Sharma, Chandra Prakash,Parveen, Sajiya,Vats, Ravi P.,Seth, Anuradha,Goel, Atul,Kar, Susanta
, (2021/05/17)
The current therapeutic regimen for visceral leishmaniasis is inadequate and unsatisfactory due to toxic side effects, high cost and emergence of drug resistance. Alternative, safe and affordable antileishmanials are, therefore, urgently needed and toward these we synthesized a series of arylpiperazine substituted pyranone derivatives and screened them against both in vitro and in vivo model of visceral leishmaniasis. Among 22 synthesized compounds, 5a and 5g showed better activity against intracellular amastigotes with an IC50 of 11.07 μM and 15.3 μM, respectively. In the in vivo, 5a significantly reduced hepatic and splenic amastigotes burden in Balb/c mice model of visceral leishmaniasis. On a mechanistic node, we observed that 5a induced direct Leishmania killing via mitochondrial dysfunction like cytochrome c release and loss of membrane potential. Taken together, our results suggest that 5a is a promising lead for further development of antileishmanial drugs.
Base-mediated alternate route for multi-functionalized allylbenzenes using ring transformation strategy
Shetgaonkar, Samata E.,Singh, Fateh V.
, p. 2511 - 2521 (2020/07/09)
A simple yet innovative approach for the construction of multi-substituted allylbenzenes 14, 16 and 18 with ‘donor-acceptor’ functionalities has been delineated through base-mediated ring transformation of 6-aryl-2H-pyran-2-ones 13, 15 and 17 respectively
Transition metal-free synthesis of sterically hindered allylarenes from 5-hexene-2-one
Althagafi, Ismail,Elagamy, Amr,Nemaysh, Vishal,Pratap, Ramendra,Rai, Reeta,Shah, Chandan,Shaw, Ranjay,Singh, Harpreet
supporting information, p. 6276 - 6286 (2020/09/07)
A simple, efficient and transition metal-free strategy was established for the synthesis of highly functionalized, sterically hindered allylarenes (6, 7 & 8) by base-mediated ring transformation of 2-oxo-6-aryl-4-(methylthio/sec-amino)-2H-pyran-3-carbonit
Base-promoted regioselective synthesis of 1,2,3,4-terahydroquinolines and quinolines from N-boc-3-piperidone
Shally,Althagafi, Ismail,Singhal, Divya,Panwar, Rahul,Shaw, Ranjay,Elagamy, Amr,Pratap, Ramendra
, (2019/11/11)
An efficient synthesis of 1,2,3,4-tetrahydroquinolines with donor and acceptor group has been delineated by base mediated ring transformation of 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles by N-boc-3-piperidone followed by consecutive deprotection
Chemoselective synthesis of isolated and fused fluorenones and their photophysical and antiviral properties
Althagafi, Ismail,Shaw, Ranjay,Tang, Cheng-Run,Panwar, Rahul,Shally,Sinha, Chanda,Kumar, Amit,Zheng, Yong-Tang,Pratap, Ramendra
, p. 7477 - 7487 (2018/10/24)
Highly functionalized fluorenones were synthesized by an intramolecular cyclization of 2′′-halo-[1,1′:3′,1′′-terphenyl]-4′-carbonitriles in the presence of n-butyllithium or lithium aluminium hydride. The precursor was synthesized by ring transformation o
Chemoselective synthesis of m-teraryls through ring transformation of 2 H-pyran-2-ones by 2-(1-arylethylidene)-malononitriles
Panwar, Rahul,Shally,Shaw, Ranjay,Elagamy, Amr,Pratap, Ramendra
, p. 8994 - 9002 (2018/12/10)
We have developed a simple, efficient and chemoselective approach for the synthesis of m-teraryls by the reaction of 6-aryl-2-oxo-4-(sec.amino)-2H-pyran-3-carbonitriles and 2-(1-arylethylidene)malononitriles under basic conditions. We used 6-aryl-2-oxo-4-
White light induced E/Z-photoisomerization of diphenylamine-tethered fluorescent stilbene derivatives: Synthesis, photophysical, and electrochemical investigation
Mishra, Shachi,Awasthi, Pallavi,Singh, Jagriti,Gupta, Rahul Kumar,Singh, Vikram,Kant, Ruchir,Jeet, Ram,Goswami, Debabrata,Goel, Atul
, p. 3669 - 3678 (2018/04/14)
A facile synthesis and detailed photophysical investigation of E/Z-isomerization of fluorescent diphenylamine tethered stilbene derivatives (DPASs) under white light exposure have been carried out to understand the effect on fluorescence, electrochemical
