134167-10-5

Upstream product

• 17325-85-8 (2S)-3-(benzyloxy)propane-1,2-diol 
• 100-39-0 benzyl bromide 
• 134167-09-2 Benzoic acid (R)-3-benzyloxy-2-hydroxy-propyl ester 
• 88753-39-3 Benzoic acid (R)-3-benzyloxy-2-methanesulfonyloxy-propyl ester 
• 14347-83-2 (R)-2,2-dimethyl-4-benzoxymethyl-1,3-dioxolane 
• 58577-87-0 O-benzyl-L-serinol 

Downstream Products

• 134167-11-6 Methanesulfonic acid 2-((S)-2-azido-3-benzyloxy-propoxy)-ethyl ester 
• 1260955-43-8 ((S)-2-azido-3-benzyloxypropoxy)-tert-butyl-dimethylsilane 

Relevant academic research and scientific papers

Synthesis of chiral 1,4-disubstituted-1,2,3-triazole derivatives from amino acids

A versatile method for the synthesis of chiral 1,4-disubstituted-1,2,3- triazole derivatives starting from easily accessible naturally occurring D-or L-amino acids as chiral synthons is described. The amino acids were converted into azido alcohols, followed by copper catalyzed [3+2] cycloaddition reactions between the azido alcohols and methyl propiolate and subsequent ester aminolysis with primary and secondary amines furnished the target compounds, which were obtained in excellent yields with no racemization. Docking of selected target compounds shows that the chiral 1,4-disubstituted-1,2,3-triazoles derivatives has the potential of mimicking the binding mode of known purine analogues.

SYNTHESIS OF AN ETHYLENE GLYCOL CROSS-LINKED AMINO ACID

Synthesis of an ethylene glycol-containing amino acid, (2R,9S)-N2-Cbz-N9-Boc-2,9-diamino-4,7-dioxadecanedioic acid 1-phenacyl 10-methyl diester 1, was studied through direct alkylation of N-Boc-L-serine and through BF3-catalyzed ring