88753-39-3

Upstream product

• 134167-09-2 Benzoic acid (R)-3-benzyloxy-2-hydroxy-propyl ester 
• 124-63-0 methanesulfonyl chloride 
• 167076-54-2 (S)-3-(Phenylmethoxy)-1,2-propandiol, 1-Benzoat 
• 14347-83-2 (R)-2,2-dimethyl-4-benzoxymethyl-1,3-dioxolane 
• 100-39-0 benzyl bromide 
• 17325-85-8 (2S)-3-(benzyloxy)propane-1,2-diol 

Downstream Products

• 17325-87-0 (2R)-1,2-diacetoxy-3-(benzyloxy)propane 
• 17325-85-8 (2S)-3-(benzyloxy)propane-1,2-diol 
• 88753-42-8 Benzoic acid (R)-2-acetoxy-3-benzyloxy-propyl ester 
• 88753-45-1 (R)-1-acetoxy-2-benzoyloxy-3-benzyloxypropane 
• 88753-42-8 Benzoic acid (S)-2-acetoxy-3-benzyloxy-propyl ester 
• 88753-45-1 Benzoic acid (S)-2-acetoxy-1-benzyloxymethyl-ethyl ester 
• 134167-11-6 Methanesulfonic acid 2-((S)-2-azido-3-benzyloxy-propoxy)-ethyl ester 
• 134167-10-5 (R)-2-azido-3-benzyloxypropan-1-ol 

Relevant academic research and scientific papers

SYNTHESIS OF AN ETHYLENE GLYCOL CROSS-LINKED AMINO ACID

Synthesis of an ethylene glycol-containing amino acid, (2R,9S)-N2-Cbz-N9-Boc-2,9-diamino-4,7-dioxadecanedioic acid 1-phenacyl 10-methyl diester 1, was studied through direct alkylation of N-Boc-L-serine and through BF3-catalyzed ring

NUCLEOPHILIC DISPLACEMENT REACTIONS OF THE METHANESULFONATES OF THE 1-O-BENZOYL-1,2-, -1,3-, AND -1,4-GLYCOLS

Nucleophilic displacement reactions of the methanesulfonates (8a-c) of the 1-O-benzoyl-1,2-, -1,3-, and -1,4-glycols (7a-c) with potassium acetate in boiling acetic anhydride have been examined.Both benzoyloxy-group participation pathway (path A) and SN2 displacement pathway (path B) have been involved in the 1,2-(8a)- and 1,3-(8b)-substrates to give a mixture of the primary (10a,b) and the secondary (11a,b) acetates with complete inversion of chiralities.On the other hand, only SN2 displacement pathway (path B) has been involved in the 1,4-substrate (8c) to give the secondary acetate (11c) with inversion of the chirality.