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134208-17-6

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134208-17-6 Usage

Uses

Antipsychotic.

Check Digit Verification of cas no

The CAS Registry Mumber 134208-17-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,2,0 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 134208-17:
(8*1)+(7*3)+(6*4)+(5*2)+(4*0)+(3*8)+(2*1)+(1*7)=96
96 % 10 = 6
So 134208-17-6 is a valid CAS Registry Number.
InChI:InChI=1/C26H35N3O2/c1-21(2)31-25-12-5-4-11-24(25)28-17-15-27(16-18-28)20-22-9-8-10-23(19-22)26(30)29-13-6-3-7-14-29/h4-5,8-12,19,21H,3,6-7,13-18,20H2,1-2H3

134208-17-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name piperidin-1-yl-[3-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]phenyl]methanone

1.2 Other means of identification

Product number -
Other names UNII-N0X1XW704P

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134208-17-6 SDS

134208-17-6Downstream Products

134208-17-6Related news

Distribution and metabolism of the antipsychotic agent Mazapertine (cas 134208-17-6) succinate in rats07/24/2019

The pharmacokinetics and drug disposition of 14C 1-[3-[[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]methyl]benzoy]piperidine succinate (RWJ-37796, mazapertine, Mz) have been investigated in male and female Sprague–Dawley rats. Approximately 93% of the orally administered radioactive dose (30 mg/...detailed

134208-17-6Relevant articles and documents

Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT(1A), and adrenergic α1 receptors

Reitz, Allen B.,Baxter, Ellen W.,Codd, Ellen E.,Davis, Coralie B.,Jordan, Alfonzo D.,Maryanoff, Bruce E.,Maryanoff, Cynthia A.,McDonnell, Mark E.,Powell, Eugene T.,Renzi, Michael J.,Schott, Mary R.,Scott, Malcolm K.,Shank, Richard P.,Vaught, Jeffry L.

, p. 1997 - 2009 (2007/10/03)

New antipsychotic drugs are needed because current therapy is ineffective for many schizophrenics and because treatment is often accompanied by extrapyramidal symptoms and dyskinesias. This paper describes the design, synthesis, and evaluation of a series of related (aminomethyl)benzamides in assays predictive of antipsychotic activity in humans. These compounds had notable affinity for dopamine D2, serotonin 5- HT(1A), and α1-adrenergic receptors. The arylpiperazine 1-[3-[[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]methyl]benzoyl]piperidine (mazapertine, 6) was chosen because of its overall profile for evaluation in human clinical trials. The corresponding 4-arylpiperidine derivative 67 was also highly active indicating that the aniline nitrogen of 6 is not required for activity. Other particularly active structures include homopiperidine amide 14 and N-methylcyclohexylamide 31.

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