134221-42-4

Upstream product

• 13265-84-4 D-glucal 
• 2873-29-2 D-glucal triacetate 
• 157612-19-6 1,6-anhydro-3-O-benzyl-4-O-(p-methoxybenzyl)-β-D-mannopyranose 
• 139437-39-1 1,6-anhydro-2-deoxy-2-iodo-β-D-glucopyranose 
• 100-39-0 benzyl bromide 
• 635683-65-7 1,6-anhydro-2-azido-2-deoxy-4-O-p-methoxybenzyl-β-D-glucopyranose 
• 157612-17-4 1,6-anhydro-2,3-O-endo-benzylidene-4-O-(p-methoxybenzyl)-β-D-mannopyranose 
• 71049-45-1 1,6-anhydro-2,3-O-endo-benzylidene-β-D-mannopyranose 
• 635683-64-6 1,6:2,3-bisanhydro-4-O-p-methoxybenzyl-β-D-glucopyranose 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1262887-44-4 C₁₈H₂₃N₃O₇ 
• 175978-55-9 methyl 2-azido-3-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 501088-17-1 methyl 2-azido-6-O-benzoyl-3-O-benzyl-2-deoxy-α-D-glucopyranoside 
• 55682-57-0 1,6-anhydro-2-azido-3-O-benzyl-2-deoxy-β-D-glucopyranose 

Relevant academic research and scientific papers

AN EFFICIENT AND SCALABLE PROCESS FOR THE MANUFACTURE OF FONDAPARINUX SODIUM

The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.

EFFICIENT AND SCALABLE PROCESS FOR THE MANUFACTURE OF FONDAPARINUX SODIUM

The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.

Use of Cerny Epoxides for the Accelerated Synthesis of Glycosaminoglycans

(Equation presented) 1,6:2,3-Dianhydrohexopyranoses (Cerny epoxides) are versatile intermediates for the synthesis of glycosaminoglycans. Complex heparan and chondroitin sulfate disaccharide synthons can be assembled from a single common precursor in a short sequence of steps.

Facile Preparation of 1,6-Anhydro-2-azido-3-O-benzyl-2-deoxy-β-D-glucopyranose and Its 4-O-Substituted Derivatives

Treatment of 1,6-anhydro-2,3-O-endo-benzylidene-β-D-mannopyranose derivatives with trimethylamine-borane (1/1)-aluminium chloride resulted in highly regioselective fission of the cyclic acetals to give the corresponding 2-O-unprotected-3-O-benzyl derivatives. Trifluoromethane-sulfonylation of these, followed by nucleophilic substitution, afforded 2-azido-2-deoxy derivatives in good yields.