1342307-11-2Relevant academic research and scientific papers
Microwave-promoted copper-free Sonogashira-Hagihara couplings of aryl imidazolylsulfonates in water
Civicos, Jose F.,Alonso, Diego A.,Najera, Carmen
, p. 203 - 208 (2013)
Aryl imidazol-1-ylsulfonates have been efficiently cross-coupled with aryl-, alkyl-, and silylacetylenes in neat water under copper-free conditions at 110 °C assisted by microwave irradiation. Using 0.5mol% of an oxime palladacycle as precatalyst, 2-dicyclohexylphosphino-2′,6′- dimethoxybiphenyl (SPhos, 2mol%) as ligand, hexadecyltrimethylammonium bromide (CTAB) as additive, and triethylamine (TEA) as base, a wide array of disubstituted alkynes has been prepared in good to high yields in only 30min. Copyright
Synthesis of 18F-Labeled Aryl Fluorosulfates via Nucleophilic Radiofluorination
Kwon, Young-Do,Jeon, Min Ho,Park, Nam Kyu,Seo, Jeong Kon,Son, Jeongmin,Ryu, Young Hoon,Hong, Sung You,Chun, Joong-Hyun
supporting information, p. 5511 - 5516 (2020/07/08)
Sulfuryl fluoride gas is a key reagent for SO2F transfer. However, conventional SO2F transfer reactions have limited 18F-radiochemistry translation, due to the inaccessibility of gaseous [18F]SO2F2. Herein, we report the first SO2F2-free synthesis of aryl [18F]fluorosulfates from both phenolic and isolated aryl imidazylate precursors with cyclotron-produced 18F-. The radiochemical yields ranged from moderate to good with excellent functional group tolerance. The reliability of our approach was validated by the automated radiosynthesis of 4-acetamidophenyl [18F]fluorosulfate.
Phosphane-free suzukimiyaura coupling of aryl imidazolesulfonates with arylboronic acids and potassium aryltrifluoroborates under aqueous conditions#
Civicos, Jose Francisco,Gholinejad, Mohammad,Alonso, Diego A.,Najera, Carmen
supporting information; experimental part, p. 907 - 909 (2011/12/05)
Aryl imidazole-1-sulfonates are efficiently cross-coupled with arylboronic acids and potassium aryltrifluoroborates using only 0.5 mol% of oxime palladacycles 1 under aqueous conditions at 110 °C. Under these simple phosphane-free reaction conditions a wide array of biaryl derivatives has been prepared in high yields. This methodology allows in situ phenol sulfonation and one-pot Suzuki arylation as well as the employment of microwave irradiation conditions.
