134255-57-5Relevant academic research and scientific papers
Chlorotrimethylsilane-promoted condensation of ketones and aminoazoles
Ryabukhin, Sergey V.,Naumchik, Vasiliy S.,Grygorenko, Oleksandr O.,Tolmachev, Andrey A.
, p. 1147 - 1150,4 (2012)
Chlorotrimethylsilane-promoted reaction of ketones and aminoazoles (i.e., 3-amino-1,2,4-triazoles, 5-aminotetrazole) at 2: 1 ratio resulted in the formation of 4,5-dihydroazolo[1,5-a]pyrimidine derivatives as the single regioisomers in 35 - 71% yields. In the case of tert-butylmethylketone and 5-aminotetrazole as the starting materials, the solvent (dimethylformamide) entered the reaction instead of the second ketone molecule.
Synthesis of dihydro-1,2,4-triazolo[1,5-a]pyrimidines
Wermann,Hartmann
, p. 189 - 191 (2007/10/02)
Several 5,7-diaryl-4,5-dihydro-5-methyl-1,2,4-triazolo[1,5-a]pyrimidines 3a-f and 5,7-diaryl-4,7-dihydro-7-methyl-1,2,4-triazolo[1,5-a]pyrimidines 4a-f were synthesized in high yield from 5-amino-1H-1,2,4-triazole (amitrole) (1) and acetophenones 2 by heating in the presence of zinc chloride and subsequent separation of the isomers.
