134259-59-9

Upstream product

• 36240-50-3 diethyl 2-cyano-2-trimethylsilylethanephosphonate 
• 100-52-7 benzaldehyde 
• 107-13-1 acrylonitrile 
• 497181-77-8 2-[(5,5-dimethyl-[1,3,2]dioxaphosphinan-2-yloxy)-phenyl-methyl]-acrylonitrile 
• 19362-96-0 2-(1-hydroxybenzyl)acrylonitrile 
• 497181-90-5 (Z)-2-(5,5-Dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-ylmethyl)-3-phenyl-acrylonitrile 
• 158426-75-6 2-benzylidene-4-phenyl-but-3-enoic acid 

Relevant academic research and scientific papers

A new manifold for the Morita reaction: Diene synthesis from simple aldehydes and acrylates/acrylonitrile mediated by phosphines

Dienes have been formed with good stereoselectivity and in good yield from simple aldehydes and acrylates/acrylonitrile in the presence of a phosphine and a Lewis acid through a modification of the Morita reaction. The Royal Society of Chemistry.

New allylphosphonates derived from (OCH2CMe2CH2O)PCl and Baylis-Hillman adducts - Stereochemistry and utility

New allylphosphonates have been prepared; an X-ray structural proof for the major Z-isomer has been given for phosphonate 3. Horner-Wadsworth-Emmons reaction of 3 or 6 (Z isomer) with aromatic aldehydes leads to carbomethoxy/ cyano substituted butadienes. In the reaction using cyanoallylphosphonate 6, use of either Z or E isomer leads to the same E,Z product; stereochemistry of one such cyano product is confirmed by X-ray crystallography. In the reaction of 3 with 4-nitrobenzaldehyde stereochemistry for the (E,E) isomer is confirmed by X-ray crystallography.