134281-65-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 150-78-7 1,4-dimethoxybezene 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 108-88-3 toluene 
• 16844-27-2 p-toluenesulfinic acid lithium salt 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 624-31-7 4-tolyl iodide 
• 103-19-5 di(p-tolyl) disulfide 
• 110624-68-5 2-(4-methylphenyl)sulfanyl-1,4-dimethoxybenzene 

Downstream Products

• 134281-72-4 3,3,6,6-tetramethoxy-1-p-tolylsulfonylcyclohexa-1,4-diene 

Relevant academic research and scientific papers

Manganese(III) Acetate Mediated C–H Sulfonylation of 1,4-Dimethoxybenzenes with Sodium and Lithium Sulfinates

A simple and mild Mn(OAc)3-promoted oxidative coupling of 1,4-dimethoxybenzenes with sodium and lithium sulfinates was developed. The reaction proceeded readily at room temperature in air, and various sulfones were synthesized in moderate to high yields. In addition, a straightforward approach for the conversion of organolithium reagents and sulfur dioxide into sulfonylated 1,4-dimethoxybenzenes was explored.

The synthesis of diarylsulfones with simple arenes and K2S2O8 through double C-S bond formation

An unprecedented double C-S bond formation method has been developed to prepare both symmetric and unsymmetric diarylsulfones with simple arenes in a single step. This represents the first example that K2S2O8 can be employed as a highly effective sulfonating agent to synthesize diarylsulfones. The reaction demonstrates excellent reactivity, good functional group tolerance and high yields.

MoO2Cl2 as a novel catalyst for Friedel-Crafts acylation and sulfonylation

The use of MoO2Cl2 as a novel catalyst for Friedel-Crafts acylation and sulfonylation is described. A series of aromatic ketones and sulfones were prepared in moderate to good yields using acyl chloride or sulfonyl chloride in the presence of MoO2Cl2 (20 mol %), under solvent-free conditions.

Highly selective catalytic Friedel-Crafts acylation and sulfonylation of activated aromatic compounds using indium metal

The Friedel-Crafts acylation of activated benzenes with various aromatic and aliphatic acid chlorides was studied in the presence of indium metal. The reaction was accomplished in high isolated yields under solvent or solvent-less conditions. The method is also applicable for preparing diaryl sulfones from aromatic compounds and aryl sulfonyl chlorides.

GENERAL SYNTHESIS OF CHIRAL 2-P-TOLYLSULFINYLQUINONES

Optically pure (S)-p-tolylsulfinyl substituted quinones were synthesized by deketalization of the corresponding quinone bisketals obtained by Andersen's type synthesis starting from 2-bromo-1,4-dimethoxy aromatic derivatives, followed by anodic oxidation