1342815-16-0

Basic information

• Product Name: N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide
• Synonyms: N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide
• CAS NO: 1342815-16-0
• Molecular Weight: 406.915
• Mol File: 1342815-16-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide(1342815-16-0)
• EPA Substance Registry System: N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide(1342815-16-0)

Safety Data

• Hazardous Substances Data: 1342815-16-0(Hazardous Substances Data)

Upstream product

• 7206-70-4 4-amino-5-chloro-2-methoxybenzoic acid 
• 132431-09-5 benzyl (piperidin-4-ylmethyl)carbamate 
• 325290-50-4 tert-butyl 4-(azidomethyl)piperidine-1-carboxylate 
• 144222-22-0 tert-butyl 4-(aminomethyl)piperidine-1-carboxylate 
• 188973-04-8 N-tert-butyloxycarbonyl-4-(4-amino-5-chloro-2-methoxyphenylcarbonylaminomethyl)piperidine 
• 161975-39-9 tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 288385-51-3 1-(3-hydroxypropyl)-1,2,3-triazole 
• 1342815-31-9 3-(1H-1,2,3-triazol-1-yl)propyl methanesulfonate 
• 6457-49-4 4-piperidinemethanol 

Relevant articles and documents

METHOD FOR PREPARING BENZAMIDE DERIVATIVE, NOVEL INTERMEDIATE USED IN PREPARATION OF BENZAMIDE, AND METHOD FOR PREPARING NOVEL INTERMEDIATE

The present invention relates to a method for preparing N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chloro-2-methoxybenzamide, which is a novel benzamide derivative as a 5-HT4 receptor agonist, or a pharmaceutically acceptable salt thereof; to a novel intermediate capable of being used in the preparation of the compounds; and to a method for preparing the same. The preparation methods of the present invention can be useful for mass production since a low-priced reagent and intermediate are used and the number of reaction processes is decreased, thereby saving preparation costs and improving the yield.

NOVEL BENZAMIDE DERIVATIVES

The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HT4 receptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HT4 receptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HT4 receptors.