1342885-25-9

Upstream product

• 220643-38-9 3',5'-O-bis(tert-butyldimethylsilyl)-2'-deoxy-5-(6-hydroxyhex-1-ynyl)uridine 
• 148134-86-5 2'-deoxy-3',5'-bis(O-tert-butyldimethylsilyl)-5-iodouridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 98-91-9 thiobenzoic acid 
• 220643-39-0 methanesulfonic acid 6-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-hex-5-ynyl ester 

Downstream Products

• 1342885-28-2 5-(6-benzoylthiohex-1-ynyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 
• 1342885-29-3 [5-(6-benzoylthiohex-1-ynyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)urid-3'-O-yl]-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 
• 1342885-26-0 5-(6-benzoylthiohex-1-ynyl)-2'-deoxyuridine 

Relevant academic research and scientific papers

Intrastrand locks increase duplex stability and base pairing selectivity

Oligodeoxynucleotide probes with disulfide locks between neighboring nucleobases show increases in melting point for duplexes with RNA target strands of up to 7.6 °C. The weakly pairing TT dimers are replaced with locked 2′-deoxy-5-(thioalkynyl)uridine re