1342948-87-1

Basic information

• Product Name: N-(3,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine
• Synonyms: N-(3,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine
• CAS NO: 1342948-87-1
• Molecular Weight: 245.231
• Mol File: 1342948-87-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine(1342948-87-1)
• EPA Substance Registry System: N-(3,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine(1342948-87-1)

Safety Data

• Hazardous Substances Data: 1342948-87-1(Hazardous Substances Data)

Upstream product

• 1041181-58-1 6-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 
• 1342812-72-9 N-(3,4-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 143468-12-6 1-Benzoyl-6-bromo-1H-pyrrolo<2,3-b>pyridine 
• 271-63-6 7-Azaindole 
• 143468-13-7 6-Bromo-1H-pyrrolo<2,3-b>pyridine 

Relevant articles and documents

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease

The aggregation of amyloid-β peptides into cytotoxic oligomeric and fibrillary aggregates is believed to be one of the major pathological events in Alzheimer disease. Here we report the design and synthesis of a novel series of indole and 7-azaindole derivatives containing, nitrile, piperidine and N-methyl-piperidine substituents at the 3-position to prevent the pathological self-assembly of amyloid-β. We have further demonstrated that substitution of the azaindole and indole derivatives at the 3 positions is required to obtain compounds with improved physicochemical properties to allow brain penetration.