134295-34-4

Upstream product

• 108-22-5 Isopropenyl acetate 
• 61592-48-1 2-Chloro-1-(4-fluorophenyl)ethanol 
• 876-27-7 4-chlorophenyl acetate 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 108-05-4 vinyl acetate 

Downstream Products

• 403-41-8 (R)-1-(4-fluorophenyl)ethan-1-ol 
• 18511-62-1 (2S)-2-(4-fluorophenyl)oxirane 
• 126534-42-7 (S)-1-chloro-2-hydroxy-2-(p-fluorophenyl)ethane 
• 134295-41-3 2-(4-Fluoro-phenyl)-2-{4-[(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-ethanol 
• 134295-39-9 (+)-1-<(S)-2-(4-fluorophenyl)-2-hydroxyethyl>-4-<(S)-(4-fluorophenyl)hydroxymethyl>-piperidine 
• 134295-38-8 (+)-1-<(S)-2-(4-fluorophenyl)-2-hydroxyethyl>-4-<(R)-(4-fluorophenyl)hydroxymethyl>-piperidine 

Relevant academic research and scientific papers

Highly enantioselective acylation of chlorohydrins using Amano AK lipase from P. fluorescens immobilized on silk fibroin-alginate spheres

Aromatic, allylic, and aliphatic compounds containing a chlorohydrin group were selected as substrates for the enzymatic kinetic resolution mediated by Amano AK lipase from Pseudomonas fluorescens immobilized in silk friboin-alginate spheres. Thus, the en

Highly efficient route for enantioselective preparation of chlorohydrins via dynamic kinetic resolution

(Equation Presented) Dynamic kinetic resolution (DKR) of various aromatic chlorohydrins with the use of Pseudomonas cepacia lipase (PS-C "Amano" II) and ruthenium catalyst 1 afforded chlorohydrin acetates in high yields and high enantiomeric excesses. These optically pure chlorohydrin acetates are useful synthetic intermediates and can be transformed to a range of important chiral compounds.

Chemoenzymatic dynamic kinetic resolution of β-halo alcohols. An efficient route to chiral epoxides

Enzymatic resolution of β-chloro alcohols in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution (conversion up to 99% and ee up to 97%). The efficiency of the DKR is dramatically reduced when β-bromo alcohols are used. The presence of the bromo substituent causes decomposition of the ruthenium catalysts, which triggers the progressive deactivation of the enzyme. The synthetic utility of this procedure has been illustrated by the practical synthesis of different chiral epoxides.

NOVEL ALKYLAMINO DERIVATIVES

Compounds represented by the following formula, such as (R,S)-1-(1-adamantyl)-2-[4-(6-chloro-2-iminobenzothiazolin-3-ylmethyl)piperidin-1-yl]ethanol, or salts thereof: X-Q-C(R1)(R2)-Z wherein R1and R2each represents hydrogen, alkyl, etc. and Z represents either of groups (a) and (b), [wherein R3represents alkyl, etc.; p is an integer of 3 to 8; R4and R5each represents hydrogen, alkyl, etc.; and B represents formula (c) (wherein R6and R7each represents hydrogen, halogeno, etc. and D represents sulfur, oxygen, etc.)].

Multigram lipase-catalyzed enantioselective acylation in the synthesis of the four stereoisomers of a new biologically active α-aryl-4-piperidinemethanol derivative

The four stereoisomers of the novel non-narcotic analgesic 1-[2-(4-fluorophenyl)-2-hydroxyethyl]-4-[(4-fluorophenyl)hydroxymethyl ]-piperidine 1 were synthesized in a convergent manner from chiral precursors 2 and 3. Optical resolution via enantioselective acylation in organic media, catalyzed by a lipase from Pseudomonas sp., was utilized in the preparation of 2 and 3 on a multigram scale with high enantiomeric purity (>97% ee).