134302-93-5

Upstream product

• 1878-29-1 ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate 
• 38330-80-2 monomethyl monopotassium malonate 

Downstream Products

• 134310-05-7 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-3-piperonyloyl-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate 
• 75404-00-1 ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylate 
• 134302-94-6 3-ethyl 2-methyl rel-(2R,3S,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-dicarboxylate 

Relevant academic research and scientific papers

Anticancer agent development; 6. Application of the heterocycle annulation-rearrangement strategy in the synthesis of a podophyllotoxin precursor

A four-step synthesis of the Bristol-Myers' precursor, ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3 ,4-tetrahydronaphthalene-3-carboxylate, to (±)-podophyllotoxin is described in 40% overall yield from ethyl 3,4,5-trimethoxy