134310-05-7

Basic information

• Product Name: 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-3-piperonyloyl-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate
• Synonyms: 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-3-piperonyloyl-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate
• CAS NO: 134310-05-7
• Molecular Weight: 530.485
• Mol File: 134310-05-7.mol

Chemical Properties

• CAS DataBase Reference: 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-3-piperonyloyl-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-3-piperonyloyl-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate(134310-05-7)
• EPA Substance Registry System: 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-3-piperonyloyl-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate(134310-05-7)

Safety Data

• Hazardous Substances Data: 134310-05-7(Hazardous Substances Data)

Upstream product

• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 134302-93-5 4-ethyl 3-methyl rel-(3R,4S,5S)-2-oxo-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3,4-dicarboxylate 
• 1878-29-1 ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate 

Downstream Products

• 134302-94-6 3-ethyl 2-methyl rel-(2R,3S,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-dicarboxylate 
• 75404-00-1 ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylate 

Relevant articles and documents

Anticancer agent development; 6. Application of the heterocycle annulation-rearrangement strategy in the synthesis of a podophyllotoxin precursor

A four-step synthesis of the Bristol-Myers' precursor, ethyl rel-(3R,4R)-6,7-methylenedioxy-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3 ,4-tetrahydronaphthalene-3-carboxylate, to (±)-podophyllotoxin is described in 40% overall yield from ethyl 3,4,5-trimethoxy