134303-31-4Relevant academic research and scientific papers
Straightforward synthesis of non-natural chalcogen peptides via ring opening of aziridines
Schwab, Ricardo S.,Schneider, Paulo H.
supporting information, p. 10449 - 10455,7 (2012/12/13)
The synthesis of new chiral non-natural seleno-, thio-, and telluro-peptides is described herein. These new compounds were prepared through simple and brief synthetic route, from inexpensive and commercially available amino acids. The products, possessing a highly modular character, were obtained in good to excellent yields (50-96%), via ring opening of aziridines with chalcogenolate anions, generated using indium(I) iodide as a reducing agent.
A novel route to N-alkylated derivatives of aziridine-2-carboxylic acid. An alternative synthesis of (S,S)-Bz-Azy-Val-OMe
Polyak,Dorofeeva,Sturkovich,Goldberg
, p. 239 - 248 (2007/10/02)
A novel method for N-alkylation of azyridine-2-carboxylic acid derivative with benzyl chloride under phase-transfer conditions or using KF/Al2O3 as a base was developed. The latter variant of this method was applied to carry out the key step of the alternative synthesis of the dipeptide (S,S)-Bz-Azy-Val-Ome.
