13433-09-5

Basic information

• Product Name: H-ASP-PHE-OH
• Synonyms: L-ALPHA-ASPARTYL-L-PHENYLALANINE;L-ASPARTYL-L-PHENYLALANINE;L-ASPARTIC ACID-L-PHENYLALANINE;GASTRIN 16-17 DEAMINATED;H-ASP-PHE-OH;ASPARTAME ACID;ALPHA-L-ASP-PHE;N-L-ALPHA-ASPARTYL-L-PHENYLALANINE
• CAS NO: 13433-09-5
• Molecular Formula: C₁₃H₁₆N₂O₅
• Molecular Weight: 280.28
• EINECS: 236-557-3
• Product Categories: Amino Acids & Derivatives;Heterocycles;Impurities;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Amino Acids & Derivatives, Heterocycles, Impurities, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 13433-09-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 236-239 °C(lit.)
• Boiling Point: 423°C (rough estimate)
• Flash Point: 317.7 °C
• Appearance: Off-white to yellow to beige to orange to tan/Powder
• Density: 1.2419 (rough estimate)
• Vapor Pressure: 2.51E-15mmHg at 25°C
• Refractive Index: 1.6450 (estimate)
• Storage Temp.: −20°C
• PKA: 3.35±0.10(Predicted)
• BRN: 2817528
• CAS DataBase Reference: H-ASP-PHE-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP-PHE-OH(13433-09-5)
• EPA Substance Registry System: H-ASP-PHE-OH(13433-09-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 13433-09-5(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Uses

L-Aspartyl-L-phenylalanine is an impurity of Thiamine (T344185). Thiamine Impurity B.

Definition

ChEBI: A dipeptide formed from L-alpha-aspartyl and L-phenylalanine residues. It is obtained after the hydrolysis of aspartame in intestinal lumen.

InChI:InChI=1/C13H16N2O5/c14-9(7-11(16)17)12(18)15-10(13(19)20)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,14H2,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,10-/m0/s1

Upstream product

• 116147-62-7 n-formyl-l-aspartic anhydride 
• 63-91-2 L-phenylalanine 
• 56633-51-3 N-formyl-L-α-aspartyl-L-phenylalanine 
• 962-39-0 L-Phenylalanine benzyl ester 
• 2577-90-4 L-phenylalanine methyl ester 
• 22839-47-0 L-Asp-L-Phe-OMe 
• 5241-71-4 Asp-Phe-NH₂ 
• 17186-36-6 N-Benzyloxycarbonyl-(β-O-benzyl-L-asparagyl)-L-phenylalanin-benzylester 

Downstream Products

• 175176-52-0 L-valyl-L-aspartyl-L-phenylalanine 
• 56-84-8 L-Aspartic acid 
• 63-91-2 L-phenylalanine 
• 22839-47-0 L-Asp-L-Phe-OMe 
• 952313-02-9 acryloyl N-α-L-aspartyl-L-phenylalanine di-methyl ester 
• 85412-56-2 methyl 3-(1-(methoxycarbonyl)-2-phenylethylcarbamoyl)-3-aminopropanoate 
• 7732-18-5 water 
• 55102-13-1 3-benzyl-6-carboxymethyl-2,5-diketopiperazine 

Relevant articles and documents

Investigations on the degradation of aspartame using high-performance liquid chromatography/tandem mass spectrometry

Aspartame is a widely used sweetener, the long-term safety of which has been controversial ever since it was accepted for human consumption. It is unstable and can produce some harmful degradation products under certain storage conditions. A high-performa

Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation

Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds. Copyright (C) 1999 Elsevier Science Ltd.

Preparation process of α-l-aspartyl-l-phenyl-alanine methyl ester or hydrohalide thereof

α-L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying α-L-aspartyl-L-phenylalanine or α-L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected-α-L-aspartyl-L-phenylalanine in an aqueou