134335-01-6Relevant academic research and scientific papers
Renin Inhibitors Containing Esters at the P2-Position. Oral Activity in a Derivative of Methyl Aminomalonate
Repine, Joseph,Himmelsbach, Richard J.,Hodges, John C.,Kaltenbronn, James S.,Sircar, Ila,et al.
, p. 1935 - 1943 (2007/10/02)
A series of renin inhibitors containing ester side chains at the P2 subsite are potent inhibitors of primate renin.Derivatives containing the diol isostere (ACDMH) at P1-P'1 were the most potent inhibitors.Moderate selectivity for re
