134340-65-1

Upstream product

• 13707-47-6 2-furaldehyde tosylimine 
• 109-72-8 n-butyllithium 
• 70-55-3 toluene-4-sulfonamide 
• 30478-77-4 1-(furan-2-yl)pentan-1-ol 
• 1453111-58-4 2-(1-azidopentyl)furan 
• 99062-45-0 1-(furan-2-yl)pentan-1-amine 
• 98-59-9 p-toluenesulfonyl chloride 
• 98-01-1 furfural 
• 135822-87-6 (E)-N-(furan-2-ylmethylene)-4-methylbenzenesulfonamide 

Downstream Products

• 134340-71-9 C₁₆H₂₁NO₄S 
• 134340-71-9 (S)-2-Butyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one 
• 944063-43-8 C₁₇H₂₃NO₄S 
• 158568-77-5 (R)-N-[1'-(2-Furyl)pentyl]toluene-p-sulfonamide 
• 134452-30-5 (S)-N-tosyl-α'-n-butyl-α-furfuryl amine 
• 134340-71-9 (R)-2-Butyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one 

Relevant academic research and scientific papers

Manganese=Catalyzed Achmatowicz Rearrangement Using Green Oxidant H2O2

Oxidation reactions have been extensively studied in the context of the transformations of biomass=derived furans. However, in contrast to the vast literature on utilizing the stoichiometric oxidants, such as m=CPBA and NBS, catalytic methods for the oxidative furan=recyclizations remain scarcely investigated. Given this, we report a means of manganese=catalyzed oxidations of furan with low loading, achieving the Achmatowicz rearrangement in the presence of hydrogen peroxide as an environmentally benign oxidant under mild conditions with wide functional group compatibility.

Alkylation of Sulfonamides with Trichloroacetimidates under Thermal Conditions

An intermolecular alkylation of sulfonamides with trichloroacetimidates is reported. This transformation does not require an exogenous acid, base, or transition metal catalyst; instead the addition occurs in refluxing toluene without additives. The sulfonamide alkylation partner appears to be only limited by sterics, with unsubstituted sulfonamides providing better yields than more encumbered N-alkyl sulfonamides. The trichloroacetimidate alkylating agent must be a stable cation precursor for the substitution reaction to proceed under these conditions.

Synthesis of 3-sulfonyloxypyridines: Oxidative ring expansion of α-furyl-sulfonamides and N→O sulfonyl transfer

N-Sulfonyl pyridinones derived from α-furylsulfonamides may be aromatised with concomitant N→O sulfonyl transfer to produce 3-sulfonyloxypyridines. Georg Thieme Verlag Stuttgart.

Synthesis of 2-aza-1-cyano-4-hydroxyanthraquinones

Phthalide annulation of 2-alkylpyridin-3-ones results in the formation of the unexpected 2-aza-1-cyano-4-hydroxy-anthraquinones, the cyano moiety originating from the 3-cyanophthalide. These compounds hold great potential against Epstein-Barr Virus Early

Stereoselective Carbon-Carbon Bond Formation via Allylic N-Sulfonyliminium Ions

N-Tosyl-6-alkoxy-2,6-dihydro-1H-pyridin-3-ones 1 were found to react stereoselectively with various nucleophiles under the influence of BF3-OEt2 yielding 2,6-cis-disubstituted dihydropyridinones.

An efficient preparation of optically active α-furfuryl amide by kinetic resolution using the modified Sharpless asymmetric epoxidation reagents

Kinetic resolution of α-furfuryl amide was first carried out by using the modified Sharpless asymmetric epoxidation reagent to give the slow-reacting enantiomers, (S)-1(a-h) and (R)-1(b,f) in high enantioselectivity (90-100% e.e) and high chemical yield (

An efficient preparation of optically active α-furfuryl amide by kinetic resolution using the modified sharpless asymmetric epoxidation reagent

Kinetic resolution of α-furfuryl amide was first carried out by using the modified Sharpless asymmetric epoxidation reagent to give the slow-reacting enantiomers, (S)-la-f and (R)-lb,f in high enantioselectivity (90-100% e.e) and high chemical yield (45-5