1343477-91-7Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of 5-chloro-3-methyl-1-substituted phenyl-1H-pyrazol-4-yl-1-phenyl pyrimidines and related compounds
Naganagowda, Gadada,Dom, Runchana Klai-U,Ariyakriangkrai, Waraporn,Luechai, Arithat,Petsom, Amorn
, p. 77 - 80 (2013/09/24)
Chalcones, (2E)-3-(5-chloro-3-methyl-1-phenyl-1 H-pyrazol-4-yl)-1- phenylprop-2-en-1-ones 1a-b have been prepared from ketone and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. These chalcones 1a-b on cyclization with urea, thiourea, hydroxylamine hydrochloride and phenyl hydrazine gave the corresponding oxopyrimidines 2a-b, thiopyrijnidines 5a-b, isoxazolines 3a-b and pyrazolines 4a-b respectively. The structures of all the synthesized compounds were confirmed by spectral data and have been screened for antibacterial, antifungal and analgesic activity.
