149873-56-3Relevant academic research and scientific papers
Synthesis of 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-(substituted phenyl)pyrimidin-2-ol analogues as anti-inflammatory and analgesic agents
Alam, Muhammad Jahangir,Ahsan, Mohamed Jawed,Alam, Ozair,Khan, Suroor Ahmad
, p. 776 - 782 (2013/12/04)
A series of 16 novel 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6- (substituted-phenyl)pyrimidin-2-ol analogues was synthesized in satisfactory yields after toxicity prediction and drug score studies by Osiris software followed by anti-inflammatory, a
Synthesis and pharmacological evaluation of 5-chloro-3-methyl-1-substituted phenyl-1H-pyrazol-4-yl-1-phenyl pyrimidines and related compounds
Naganagowda, Gadada,Dom, Runchana Klai-U,Ariyakriangkrai, Waraporn,Luechai, Arithat,Petsom, Amorn
, p. 77 - 80 (2013/09/24)
Chalcones, (2E)-3-(5-chloro-3-methyl-1-phenyl-1 H-pyrazol-4-yl)-1- phenylprop-2-en-1-ones 1a-b have been prepared from ketone and 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. These chalcones 1a-b on cyclization with urea, thiourea, hydroxylamine hydrochloride and phenyl hydrazine gave the corresponding oxopyrimidines 2a-b, thiopyrijnidines 5a-b, isoxazolines 3a-b and pyrazolines 4a-b respectively. The structures of all the synthesized compounds were confirmed by spectral data and have been screened for antibacterial, antifungal and analgesic activity.
Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro- 3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline
Girisha,Kalluraya, Balakrishna,Narayana, Vijaya,Padmashree
experimental part, p. 4640 - 4644 (2010/10/19)
A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively.
Design, synthesis, and characterization of some novel pyrazolo [1,5-a] pyrimidines as potent antimicrobial agents
Dawane, Bhaskar S.,Konda, Shankaraiah G.,Zangade, Sainath B.
experimental part, p. 1250 - 1254 (2010/11/18)
(Chemical Equation Presented) A novel series of pyrazolo [1,5-a] pyrimidines were synthesized by the condensation of substituted chalcones with 5-amino pyrazole in presence of dimethyl formamide. All the synthesized products were characterized by the spec
