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134362-34-8

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134362-34-8 Usage

General Description

(S)-2-tert-butoxycarbonylamino-3-(4-fluoro-phenyl)-propionic acid methyl ester is a chemical compound that is used in the production of pharmaceuticals. It is a methyl ester derivative of a compound with potential analgesic and anti-inflammatory properties. (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID METHYL ESTER functions as a selective COX-2 inhibitor, which means it can reduce inflammation and pain without affecting the stomach lining. It is also used as a building block in the synthesis of other pharmaceutical compounds. The compound's chemical structure allows it to selectively target the COX-2 enzyme, which is involved in the inflammatory response. This makes it a valuable ingredient in the development of new drugs for pain management and inflammatory conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 134362-34-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,3,6 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134362-34:
(8*1)+(7*3)+(6*4)+(5*3)+(4*6)+(3*2)+(2*3)+(1*4)=108
108 % 10 = 8
So 134362-34-8 is a valid CAS Registry Number.

134362-34-8Relevant articles and documents

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

Agejas, Javier,Barberis, Mario,De Frutos, Oscar,Faraggi, Tomer M.,García-Cerrada, Susana,MacMillan, David W. C.,Mateos, Carlos,Rincón, Juan A.,Rouget-Virbel, Caroline

, p. 1966 - 1973 (2021/08/18)

We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogues of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technology.

Evidence for the role of tetramethylethylenediamine in aqueous negishi cross-coupling: Synthesis of nonproteinogenic phenylalanine derivatives on water

Ross, Andrew J.,Dreiocker, Frank,Schae Fer, Mathias,Oomens, Jos,Meijer, Anthony J.H.M.,Pickup, Barry T.,Jackson, Richard F.W.

scheme or table, p. 1727 - 1734 (2011/05/30)

The structure of the alkylzinc-tetramethylethylenediamine (TMEDA) cluster cation 3 has been determined in the gas phase by a combination of tandem mass spectrometry, infrared multiphoton dissociation (IRMPD) spectroscopy, and DFT calculations. Both sets of experimental results establish the existence of a strongly stabilizing interaction of TMEDA with the zinc cation. High-level DFT calculations on the alkylzinc-TMEDA cluster cation 3 allowed the identification of two low energy conformers, each featuring a four-coordinate zinc atom with a bidentate TMEDA ligand, and internal coordination from the carbonyl group of the Boc group to zinc. The experimental IRMPD spectrum is reproduced with an appropriately weighted combination of the IR spectra of the two conformers identified by theory. DFT calculations on the structure of the alkylzinc halide 2 with coordinated TMEDA using the PCM model of water solvent suggest that TMEDA can promote ionization of the zinc-iodine bond in organozinc iodides under aqueous conditions, providing a credible explanation for the role of TMEDA in stabilizing the carbon-zinc bond. Reaction of the serine-derived iodide 1 with aryl iodides "on water", promoted by nano zinc in the presence of PdCl2 (Amphos) 2 (5 mol %) and TMEDA, leads to the formation of protected phenylalanine derivatives 4 in reasonable yields. In the case of ortho-substituted aryl iodides and aryl iodides that are solids at room temperature, conducting the reaction at 65°C gives improved results. In all cases, the product 5 of reductive dimerization of the iodide 1 is also isolated.

FLUORINATION OF ORGANIC COMPOUNDS

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Page/Page column 117; 118, (2010/07/10)

Methods for fluorinating organic compounds are described herein.

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