134369-58-7

Upstream product

• 62476-56-6 3-amino-2,6-dichloropyridine 
• 4349-62-6 2-benzyloxybenzoyl chloride 
• 7440-44-0 pyrographite 
• 69-72-7 salicylic acid 

Downstream Products

• 140413-07-6 3-Chloro-11-methyl-11H-5-oxa-4,11-diaza-dibenzo[a,d]cyclohepten-10-one 
• 140413-08-7 3-Chloro-11-ethyl-11H-5-oxa-4,11-diaza-dibenzo[a,d]cyclohepten-10-one 
• 140413-09-8 3-Chloro-11-propyl-11H-5-oxa-4,11-diaza-dibenzo[a,d]cyclohepten-10-one 
• 134369-51-0 2-chloro-5-(methylthioethyl)pyrido[2,3-b][1,4]benzoxazepin-6(5H)one 

Relevant academic research and scientific papers

Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -thiones and their use in the prevention or treatment of HIV-1 infection

Compounds of the class of pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -thiones, having the following general structural formula STR1 wherein either X or Z is sulfur and the other substituent is oxygen or both X and Z are sulfur, which are inhibitors of HIV-1 reverse transcriptase and useful in the treatment of HIV-1 infection. An exemplary compound is 2-chloro-5-(methylthioethyl)pyrido[2,3-b][1,4]benzoxazepin-6(5H)one.

Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones

Dibenzoxazepin-11(10H)-ones (III), pyridobenzoxazepin-6(5H)-ones (IV), and pyridobenzoxazepin-5(6H)-ones (V) were found to inhibit human immunodeficiency virus type 1 reverse transcriptase with IC50 values as 19 nM.A-ring substitution has a profound effect on activity, with appropriate substituents at the positions ortho and para to the lactam nitrogen providing dramatically enhanced potency.Substitution in the C-ring is generally neutral or detrimental to activity.Although a C-ring amino substituent at the position meta to the lactam carbonyl is generally beneficial to activity, it has essentially no effect when the A-ring is optimally substituted.Like the dipyridodiazepinone nevirapine, compounds III-V are specific for HIV-1 RT, exhibiting no inhibitory activity against HIV-2 RT or other virial reverse transcriptase enzymes.