1343799-97-2Relevant academic research and scientific papers
Auto-oxidative hydroxysulfenylation of alkenes
Huo, Congde,Wang, Yajun,Yuan, Yong,Chen, Fengjuan,Tang, Jing
, p. 7233 - 7236 (2016)
One-pot auto-oxidation mediated hydroxysulfenylation of electron-deficient and electron-rich olefins with phenthiols was explored. The method illustrates a selective and convenient synthesis of complex β-hydroxysulfides using O2 as both the oxidant and the oxygen source under mild transition-metal-free conditions. The application of this new methodology to the gram-scale synthesis of anti-cancer drug bicalutamide has been accomplished in a two-step sequence with 71% overall yield. A plausible radical involved mechanism is proposed.
1,2,4-Oxadiazoles: A new class of anti-prostate cancer agents
Khatik, Gopal L.,Kaur, Jasmine,Kumar, Varun,Tikoo, Kulbhushan,Nair, Vipin A.
scheme or table, p. 1912 - 1916 (2012/04/04)
Sulfide and sulfonyl derivatives of 1,2,4-oxadiazoles were synthesized and screened by MTT assay on the prostate cancer cells, DU-145. Six compounds were identified as potential anti-prostate cancer agents with IC50 values ranging from 0.5 to 5
