134391-61-0Relevant articles and documents
Transition-Metal-Free Radical Hydrotrifluoromethylation of Alkynes
Matcha, Kiran,Antonchick, Andrey P.
, p. 309 - 312 (2019)
A combination of readily available and bench-stable CF3SO2Na and tBuOOH was efficiently used for hydrotrifluoromethylation of alkynes. An excellent trans-selectivity was demonstrated in the synthesis of alkenes. The developed mild reaction conditions allow the supression of the competing Meyer–Schuster-type rearrangement.
Regioselective nucleophilic 1,4-trifluoromethylation of 2-polyfluoroalkylchromones with (trifluoromethyl)trimethylsilane. Synthesis of fluorinated analogs of natural 2,2-dimethylchroman-4-ones and 2,2-dimethylchromenes
Sosnovskikh, Vyacheslav Ya.,Usachev, Boris I.,Sevenard, Dmitri V.,Roeschenthaler, Ged-Volker
, p. 7747 - 7754 (2003)
Reactions of 2-polyfluoroalkylchromones with (perfluoroalkyl)trimethylsilanes proceed as a 1,4-nucleophilic perfluoroalkylation to give 2,2-bis(polyfluoroalkyl)chroman-4-ones with high regioselectivity and good yields after acid hydrolysis. Oxidation of 6-methyl-2,2-bis(trifluoromethyl)chroman-4-one with a mixture of K 2S2O8 and CuSO4 in aqueous acetonitrile leads to fluorinated analogues of natural lactarochromal and the corresponding acid. Reduction of substituted 2,2-bis-(trifluoromethyl)chroman-4-one with sodium borohydride in methanol and subsequent dehydration of chromanols in refluxing xylene in the presence of p-toluene sulfonic acid gives 2,2-bis-(trifluoromethyl)chromenes, which are fluorinated analogues of natural precocenes.
Synthesis of Perfluoroalkylated Indenes
Gassman, Paul G.,Ray, Julia A.,Wenthold, Paul G.,Mickelson, John W.
, p. 5143 - 5146 (2007/10/02)
A series of perfluoroalkylated indenes has been synthesized using four different synthetic pathways. 1-(Pentafluoroethyl)indene and 2-(pentafluoroethyl)indene were prepared by the addition of (pentafluoroethyl)lithium to the appropriate ketones and subseq
