1344034-03-2

Upstream product

• 1344034-01-0 2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazole-4-carboxylic acid 
• 100-51-6 benzyl alcohol 
• 101066-61-9 2-chloropyridine-4-carbaldehyde 
• 603-81-6 2,3-diaminobenzoic acid 

Downstream Products

• 1344034-06-5 tert-butyl 4-(4-(2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)benzyl)piperazine-1-carboxylate 
• 1344034-08-7 tert-butyl 4-(4-(2-(2-(3-(dimethylamino)propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)benzyl)piperazine-1-carboxylate 
• 1344034-11-2 tert-butyl 4-(4-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)benzyl)piperazine-1-carboxylate 
• 1344034-12-3 tert-butyl 3-(3-(2-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate 
• 1344034-13-4 tert-butyl 3-(3-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-ylcarbamoyl)phenyl)pyrrolidine-1-carboxylate 
• 1344033-83-5 N-(2-(2-(propylamino)pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)-3-(pyrrolidin-3-yl)benzamide hydrochloride 

Relevant academic research and scientific papers

SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS

Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I)-(XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free-substrate SIRT1 activator compounds of formulas (XL), (XI), (XII), and (XIII).