1344122-66-2

Upstream product

• 1344122-60-6 C₂₄H₄₄N₂O₈Si₂ 
• 174497-93-9 2'-O-methylthiomethyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 

Downstream Products

• 1344122-72-0 C₄₂H₅₃N₄O₁₀P 

Relevant academic research and scientific papers

Synthesis and properties of novel 20-O-alkoxymethyl-modified nucleic acids

Novel 2′-O-modified oligoribonucleotides with alkoxymethyl skeletons were synthesized, and their ability to hybridize complementary nucleic acids and their nuclease resistance were analyzed. The hybridization ability was improved by introducing electron-withdrawing groups and the increases in melting temperature (Tm value) was particularly high for chlorine-substituted compounds. Nuclease resistance of these 2′-O-alkoxymethylated oligomers was lower than expected, but cyano substitution resulted in a higher nuclease resistance than 2′-O-methylation.