1344122-75-3

Upstream product

• 1344122-63-9 2'-O-(2,2,2-trichloro)ethoxymethyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 1344122-69-5 2'-O-(2,2,2-trichloro)ethoxymethyl-5'-O-(4,4'-dimethoxytrityl)uridine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 174497-93-9 2'-O-methylthiomethyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 

Relevant academic research and scientific papers

2'-O-MODIFIED RNA

[Problem] To provide a 2'-modified ribonucleoside or the like which has a high duplex-forming ability. [Solution] The present invention is generally based on the finding in embodiments that a modified form of a ribonucleoside or the like having an alkoxym

Synthesis and properties of novel 20-O-alkoxymethyl-modified nucleic acids

Novel 2′-O-modified oligoribonucleotides with alkoxymethyl skeletons were synthesized, and their ability to hybridize complementary nucleic acids and their nuclease resistance were analyzed. The hybridization ability was improved by introducing electron-withdrawing groups and the increases in melting temperature (Tm value) was particularly high for chlorine-substituted compounds. Nuclease resistance of these 2′-O-alkoxymethylated oligomers was lower than expected, but cyano substitution resulted in a higher nuclease resistance than 2′-O-methylation.