134419-97-9

Usage

General Description

1-Propen-1-one, 2-(4-methylphenyl)-, also known as p-tolyl vinyl ketone, is an organic compound commonly used in the production of pharmaceuticals, perfumes, and other fine chemicals. It is a colorless to pale yellow liquid with a fruity aroma, and it is flammable and highly reactive. This chemical is primarily used as an intermediate in the synthesis of various compounds, including pharmaceuticals like anti-inflammatory drugs, and in the production of fragrances for perfumes and personal care products. It is important to handle and store this chemical with care due to its flammability and reactivity.

Upstream product

• 51631-67-5 α-methyl 4-methylphenylacetyl chloride 

Downstream Products

• 1185154-63-5 (S)-3-methyl-3-(p-tolyl)indolin-2-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Asymmetric [8+2] Dipolar Cycloadditions of Vinyl Carbamates and Photogenerated Ketenes

Higher-order cycloadditions, particularly [8+2] cycloadditions, are a straightforward and efficient strategy for constructing significant medium-sized architectures. Typically, configuration-restrained conjugated systems are utilized as 8π-components for

Mechanistic Investigations of the Pd-Catalyzed Hydrogenolysis of Ketene Heterodimer β-Lactones

Catalytic hydrogenolysis of the Z-isomer of a series of aryl-substituted ketene heterodimer β-lactones facilitated access to deoxypropionate derivatives with a dr ranging from 54:46 to 86:14, favoring the anti-isomer, and with excellent transfer of chiral

A photoinduced Wolff rearrangement/Pd-catalyzed [3+2] cycloaddition sequence: An unexpected route to tetrahydrofurans

A novel sequential reaction that combines a visible light-induced Wolff rearrangement of α-diazoketones and a Pd-catalyzed [3+2] cycloaddition of vinyl cyclopropanes with the resulting ketenes is described in this work. Selective O-allylic alkylation was observed over C-allylic alkylation, which unexpectedly led to a series of highly functionalized tetrahydrofurans with high efficiency (20 examples, 58-99% yields).

An asymmetric hetero-claisen approach to 3-alkyl-3-aryloxindoles

The reaction of a chiral N-phenylnitrone derived from Garner's aldehyde with alkylarylketenes generates 3-alkyl-3-aryloxindoles directly in excellent yields and with good to excellent levels of enantioselectivity (up to 90% ee).

Ketene-diene [4 + 2] cycloaddition products via cation radical initiated diels-alder reaction or vinylcyclobutanone rearrangement

Whereas the thermal reaction of the aryl methyl ketenes 1a and 1b with 2 resulted, as anticipated, in the periselective formation of the vinylcyclobutanones 3-6, the aminium ion salt initiated cycloaddition afforded selectively the Diels-Alder products 10