13443-54-4

Basic information

• Product Name: 3,4-dimethoxyphenylglycolic acid
• Synonyms: 3,4-dimethoxyphenylglycolic acid
• CAS NO: 13443-54-4
• Molecular Weight: 212.202
• Mol File: 13443-54-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3,4-dimethoxyphenylglycolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethoxyphenylglycolic acid(13443-54-4)
• EPA Substance Registry System: 3,4-dimethoxyphenylglycolic acid(13443-54-4)

Safety Data

• Hazardous Substances Data: 13443-54-4(Hazardous Substances Data)

Upstream product

• 32407-67-3 ethyl-2-(3,4-dimethoxyphenyl)-2-hydroxyacetate 
• 75-25-2 Bromoform 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 4732-70-1 3,4-dimethoxyphenylglyoxylic acid 
• 7732-18-5 water 
• 91-16-7 1,2-dimethoxybenzene 
• 298-12-4 Glyoxilic acid 
• 6309-18-8 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile 
• 2911-73-1 α-hydroxy-3,4-dimethoxyphenylacetic acid methyl ester 
• 186581-53-3 diazomethane 
• 67-66-3 chloroform 
• 54799-94-9 methyl 3-hydroxy-4-methoxymandelate 

Downstream Products

• 900175-69-1 benzyl 2-chloro-2-(3,4-dimethoxyphenyl)acetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 31542-77-5 6-hydroxy-3-(3',4'-dimethoxyphenyl)-benzofuranone 
• 528-63-2 veraguensin 
• 1241839-35-9 butyl 3,4-dimethoxymandelate 
• 900175-68-0 benzyl 2-(3,4-dimethoxyphenyl)-2-hydroxyacetate 
• 2911-73-1 α-hydroxy-3,4-dimethoxyphenylacetic acid methyl ester 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of 3-arylbenzofuranone derivatives as potential anti-Alzheimer’s disease agents

Multi-target drugs can better address the cascade of events involved in oxidative stress and the reduction in cholinergic transmission that occur in Alzheimer’s disease than cholinesterase inhibitors alone. We synthesised a series of 3-arylbenzofuranone derivatives and evaluated their antioxidant activity, cholinesterase inhibitory activity, and monoamine oxidase inhibitory activity. 3-Arylbenzofuranone compounds exhibit good antioxidant activity as well as selective acetylcholinesterase inhibitory activity. The IC50 value of anti-acetylcholinesterase inhibition of Compound 20 (0.089 ± 0.01 μM) is similar to the positive drug donepezil (0.059 ± 0.003 μM). According to the experimental results, Compounds 7, 13 show a certain effect in the in?vitro evaluation performed and have the potential as drug candidates for the treatment of Alzheimer’s disease.

A veratraldehyde synthesis method

The invention provides a veratraldehyde synthesis method which comprises the following steps: preparing an intermediate that is 3,4-dimethoxyphenylglycollic acid, and performing an oxidation reaction.According to the method, the reaction yield is high, the yield of the prepared intermediate 3,4-dimethoxyphenylethanolic acid is 95.27-97.47%, the yield of the step of oxidation reaction to prepare veratraldehyde is 98.79-99.36%, and the total yield of veratraldehyde in the two steps of reaction is 94.16-96.78%; the raw material conversion rate is high and reaches 99.5%; reaction time is short, the step (1) needs 1-2h, and the step 2) needs 0.25-2h; product purity is high, the purity of the prepared intermediate 3,4-dimethoxyphenylethanolic acid is 98.8-99.2%, the purity of the prepared veratraldehyde is 99.3-99.7%; the method is simple in reaction process, environment-friendly, free of use of high-pollution raw materials, and low in production cost.

BENZOPHENANTHRIDINES V. INVESTIGATION OF THE RODIONOV-SUVOROV SCHEME. SYNTHESIS OF 3,3-DIETHOXYCARBONYL-2-(3,4-DIMETHOXYPHENYL)-6,7-DIMETHOXY-1-TETRALONE

Triethyl 1,3-bis(3,4-dimethoxyphenyl)propane-1,2,2-tricarboxylate was synthesized by the alkylation of the lithium enolate of ethyl homoveratrate with α-bromo(3,4-dimethoxybenzyl)malonic ester.It was converted by intramolecular acylation, catalyzed by BF3