134435-71-5Relevant academic research and scientific papers
Improved regioselectivity of lithiation of methoxybenzaldehydes
Duval,Waigh
, p. 43 - 48 (2007/10/02)
Protection of the aldehyde moiety as a N,N'-diisopropylimidazolidine allows improved preferential lithiation ortho to the methoxy group of 4- methoxybenzaldehyde or in the 4-position of 3- methoxybenzaldehyde. Reaction with a suitable electrophile, such as dimethyldisulphide, gives good yields of 3-substituted-4-methoxybenzaldehydes or moderate yields of 4-substituted-3-methoxybenzaldehydes as appropriate.
