23229-39-2

Basic information

• Product Name: 2-(4-Methoxyphenyl)-1,3-dimethylimidazolidine
• Synonyms: 2-(4-Methoxyphenyl)-1,3-dimethylimidazolidine
• CAS NO: 23229-39-2
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.2841
• Mol File: 23229-39-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 281°Cat760mmHg
• Flash Point: 79.8°C
• Appearance: /
• Density: 1.036g/cm³
• Vapor Pressure: 0.00366mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 2-(4-Methoxyphenyl)-1,3-dimethylimidazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxyphenyl)-1,3-dimethylimidazolidine(23229-39-2)
• EPA Substance Registry System: 2-(4-Methoxyphenyl)-1,3-dimethylimidazolidine(23229-39-2)

Safety Data

• Hazardous Substances Data: 23229-39-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H18N2O/c1-13-8-9-14(2)12(13)10-4-6-11(15-3)7-5-10/h4-7,12H,8-9H2,1-3H3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 110-70-3 N,N`-dimethylethylenediamine 

Downstream Products

• 124639-30-1 4‐methoxy‐2‐(methylthio)benzaldehyde 
• 124639-33-4 2-(4-methoxy-3-methylthiophenyl)-1,3-dimethylimidazolidine 
• 134435-70-4 2-(4-methoxy-2-methylthiophenyl)-1,3-dimethylimidazolidine 
• 134435-71-5 2-(4-methoxy-2,5-dimethylthiophenyl)-1,3-dimethylimidazolidine 

Relevant articles and documents

From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: A rational approach towards improved cleavable linkers for biospecific endosomal release

pH-Sensitive linkers designed to undergo selective hydrolysis at acidic pH compared to physiological pH can be used for the selective release of therapeutics at their site of action. In this paper, the hydrolytic cleavage of a wide variety of molecular structures that have been reported for their use in pH-sensitive delivery systems was examined. A wide variety of hydrolytic stability profiles were found among the panel of tested chemical functionalities. Even within a structural family, a slight modification of the substitution pattern has an unsuspected outcome on the hydrolysis stability. This work led us to establish a first classification of these groups based on their reactivities at pH 5.5 and their relative hydrolysis at pH 5.5 vs. pH 7.4. From this classification, four representative chemical functions were selected and studied in-vitro. The results revealed that only the most reactive functions underwent significant lysosomal cleavage, according to flow cytometry measurements. These last results question the acid-based mechanism of action of known drug release systems and advocate for the importance of an in-depth structure-reactivity study, using a tailored methodology, for the rational design and development of bio-responsive linkers.

Compounds and pharmaceutical use thereof

PCT No. PCT/JP97/00291 Sec. 371 Date Aug. 6, 1998 Sec. 102(e) Date Aug. 6, 1998 PCT Filed Feb. 6, 1997 PCT Pub. No. WO97/29079 PCT Pub. Date Aug. 14, 1997The compounds of the formula (I) wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and pharmaceutical use thereof. The Compound (I) and pharmaceutically acceptable salts thereof of the present invention selectively act on cannabinoid receptors, particularly peripheral receptors, cause less side effects on the central system, and have superior immunoregulating action, antiinflammatory action, antiallergic action and therapeutic effect on nephritis. Therefore, they are useful as cannabinoid receptor, particularly peripheral cannabinoid receptor activators and antagonists, immunoregulators, therapeutic agents for autoimmune diseases, antiinflammatory agents, antiallergic agents and therapeutic agents for nephritis.

Comparative radioprotective activity of various pentagonal compounds with two heteroatomes

Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.