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134443-99-5

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134443-99-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 134443-99-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,4,4 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 134443-99:
(8*1)+(7*3)+(6*4)+(5*4)+(4*4)+(3*3)+(2*9)+(1*9)=125
125 % 10 = 5
So 134443-99-5 is a valid CAS Registry Number.

134443-99-5Relevant academic research and scientific papers

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection

Wisastra, Rosalina,Kok, Petra A.M.,Eleftheriadis, Nikolaos,Baumgartner, Matthew P.,Camacho, Carlos J.,Haisma, Hidde J.,Dekker, Frank J.

, p. 7763 - 7778 (2014/01/06)

Lipoxygenases (LOXs) and cyclooxygenases (COXs) metabolize poly-unsaturated fatty acids into inflammatory signaling molecules. Modulation of the activity of these enzymes may provide new approaches for therapy of inflammatory diseases. In this study, we screened novel anacardic acid derivatives as modulators of human 5-LOX and COX-2 activity. Interestingly, a novel salicylate derivative 23a was identified as a surprisingly potent activator of human 5-LOX. This compound showed both non-competitive activation towards the human 5-LOX activator adenosine triphosphate (ATP) and non-essential mixed type activation against the substrate linoleic acid, while having no effect on the conversion of the substrate arachidonic acid. The kinetic analysis demonstrated a non-essential activation of the linoleic acid conversion with a KA of 8.65 μM, αKA of 0.38 μM and a β value of 1.76. It is also of interest that a comparable derivative 23d showed a mixed type inhibition for linoleic acid conversion. These observations indicate the presence of an allosteric binding site in human 5-LOX distinct from the ATP binding site. The activatory and inhibitory behavior of 23a and 23d on the conversion of linoleic compared to arachidonic acid are rationalized by docking studies, which suggest that the activator 23a stabilizes linoleic acid binding, whereas the larger inhibitor 23d blocks the enzyme active site.

Solution processable symmetric 4-alkylethynylbenzene end-capped anthracene derivatives

Jang, Sang Hun,Kim, Hyunjin,Hwang, Min Ji,Jeong, Eun Bin,Yun, Hui Jun,Lee, Dong Hoon,Kim, Yun-Hi,Park, Chan Eon,Yoon, Yong-Jin,Kwon, Soon-Ki,Lee, Sang-Gyeong

experimental part, p. 541 - 548 (2012/05/05)

New candidates composed of anthracene and 4-alkylethynylbenzene end-capped oligomers for OTFTs were synthesized under Sonogashira coupling reaction conditions. All oligomers were characterized by FT-IR, mass, UV-visible, and PL emission spectrum analyses, cyclic voltammetry (CV), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), 1H-NMR, and 13C-NMR. Investigation of their physical properties showed that the oligomers had high oxidation potential and thermal stability. Thin films of DHPEAnt and DDPEAnt were characterized by spin coating them onto Si/SiO 2 to fabricate top-contact OTFTs. The devices prepared using DHPEAnt and DDPEAnt showed hole field-effect mobilities of 4.0 × 10-3 cm2/Vs and 2.0 × 10-3 cm2/Vs, respectively, for solution-processed OTFTs.

Synthesis and electronic properties of semiconducting polymers containing benzodithiophene with alkyl phenylethynyl substituents

Sista, Prakash,Nguyen, Hien,Murphy, John W.,Hao, Jing,Dei, Daniel K.,Palaniappan, Kumaranand,Servello, John,Kularatne, Ruvini S.,Gnade, Bruce E.,Xue, Bofei,Dastoor, Paul C.,Biewer, Michael C.,Stefan, Mihaela C.

experimental part, p. 8063 - 8070 (2011/12/15)

Semiconducting polymers containing benzodithiophene with decyl phenylethynyl and hexadecyl phenylethynyl substituents have been synthesized by Stille coupling polymerization. The optoelectronic properties of the synthesized polymers have been investigated

NOVEL ORGANIC SEMICONDUCTOR COMPOUND, AND ORGANIC THIN FILM TRANSISTOR USING THE SAME

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Page/Page column 33-34, (2008/12/04)

The present invention relates to novel mono- molecular organic semiconductor compounds and organic thin film transistors comprising the same. The organic semiconductor compounds according to the present invention are characterized by a structure of an acene derivative substituted with acetylene groups at both ends, a structure of anthracene derivative substituted with acetylene groups, or a structure of a multi-nuclear aromatic derivative functionalized by naphthalene having an electron-donor substituent at both ends.

Synthesis of new iridium complexes and their electrophosphorescent properties in polymer light-emitting diodes

Zhu, Weiguo,Liu, Chuanzhen,Su, Lijun,Yang, Wei,Yuan, Ming,Cao, Yong

, p. 50 - 55 (2007/10/03)

Several new iridium complexes with p-substituted 2-phenylpyridine (R-PPy) ligands have been synthesized and characterized. The complexes were incorporated into phosphorescent polymer light-emitting devices using soluble poly[1,4-bis(6′-cyano-6′-methylhept

Room-temperature discotic nematic liquid crystals

Kumar, Sandeep,Varshney, Sanjay Kumar,Chauhan, Diwakar

, p. 241 - 250 (2007/10/03)

The use of discotic nematic liquid crystals instead of calamitic nematic liquid crystals to improve the viewing angle of a liquid crystal display device has recently been reported. Compared to the large number of calamitic molecules showing nematic phase at room temperature, the number of disk-shaped molecules showing subambient discotic nematic phase ND are rare. In this paper we present the design, synthesis, mesomorphic behaviour and structureproperty relationship of discotic nematic liquid crystals based on benzene multiyne core.

The Effect of Carbonyl Containing Substituents in the Terminal Chains on Mesomorphic Properties in Some Aromatic Esters and Thioesters 7. α-Keto Group on the Acid End of Phenylbenzoates and Thiobenzoates

Neubert, M. E.,Sharma, R. B.,Citano, C.,Jirousek, M. R.,Paulin, J. L.

, p. 145 - 155 (2007/10/02)

A few esters/thioesters of the type with Z=O, Y=C10, OC10 and Z=S, Y=C5, C10, OC5, OC12 were prepared by esterification of the α-keto acid with the appropriate phenol or thiol using the carbodiimide method.Mesomorphic properties were determined

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