744246-56-8

Upstream product

• 108-86-1 bromobenzene 
• 106418-67-1 1-bromo-4-n-decyl benzene 
• 1066-54-2 trimethylsilylacetylene 
• 112-13-0 n-decanoyl chloride 
• 134443-99-5 1-(4-bromophenyl)decan-1-one 

Downstream Products

• 1246263-85-3 4,8-bis(4-decylphenylethynyl)benzo[1,2-b:4,5-b']dithiophene 
• 1246263-87-5 2,6-dibromo-4,8-bis(4-decylphenylethynyl)benzo-[1,2-b:4,5-b']dithiophene 
• 126708-45-0 1-decyl-4-ethynylbenzene 
• 1065644-38-3 2,6-bis[2-(4-decylphenyl)ethynyl]anthracene 

Relevant academic research and scientific papers

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection

Lipoxygenases (LOXs) and cyclooxygenases (COXs) metabolize poly-unsaturated fatty acids into inflammatory signaling molecules. Modulation of the activity of these enzymes may provide new approaches for therapy of inflammatory diseases. In this study, we screened novel anacardic acid derivatives as modulators of human 5-LOX and COX-2 activity. Interestingly, a novel salicylate derivative 23a was identified as a surprisingly potent activator of human 5-LOX. This compound showed both non-competitive activation towards the human 5-LOX activator adenosine triphosphate (ATP) and non-essential mixed type activation against the substrate linoleic acid, while having no effect on the conversion of the substrate arachidonic acid. The kinetic analysis demonstrated a non-essential activation of the linoleic acid conversion with a KA of 8.65 μM, αKA of 0.38 μM and a β value of 1.76. It is also of interest that a comparable derivative 23d showed a mixed type inhibition for linoleic acid conversion. These observations indicate the presence of an allosteric binding site in human 5-LOX distinct from the ATP binding site. The activatory and inhibitory behavior of 23a and 23d on the conversion of linoleic compared to arachidonic acid are rationalized by docking studies, which suggest that the activator 23a stabilizes linoleic acid binding, whereas the larger inhibitor 23d blocks the enzyme active site.

Solution processable symmetric 4-alkylethynylbenzene end-capped anthracene derivatives

New candidates composed of anthracene and 4-alkylethynylbenzene end-capped oligomers for OTFTs were synthesized under Sonogashira coupling reaction conditions. All oligomers were characterized by FT-IR, mass, UV-visible, and PL emission spectrum analyses, cyclic voltammetry (CV), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), 1H-NMR, and 13C-NMR. Investigation of their physical properties showed that the oligomers had high oxidation potential and thermal stability. Thin films of DHPEAnt and DDPEAnt were characterized by spin coating them onto Si/SiO 2 to fabricate top-contact OTFTs. The devices prepared using DHPEAnt and DDPEAnt showed hole field-effect mobilities of 4.0 × 10-3 cm2/Vs and 2.0 × 10-3 cm2/Vs, respectively, for solution-processed OTFTs.

Synthesis and electronic properties of semiconducting polymers containing benzodithiophene with alkyl phenylethynyl substituents

Semiconducting polymers containing benzodithiophene with decyl phenylethynyl and hexadecyl phenylethynyl substituents have been synthesized by Stille coupling polymerization. The optoelectronic properties of the synthesized polymers have been investigated