134454-82-3

Upstream product

• 15190-13-3 (4-methoxy-phenyl)-morpholin-4-yl-acetonitrile 
• 65673-83-8 5-(chloromethyl)-6-iodobenzo[d][1,3]dioxole 
• 1314025-23-4 1'-(3,4-methylenedioxyphenyl)-2'-(4''-methoxyphenyl)ethan-2'-one 
• 100-66-3 methoxybenzene 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 

Downstream Products

• 134454-86-7 1-(4'-methoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol 
• 134454-90-3 1-(4'-methoxyphenyl)-4,5-methylenedioxybenzocyclobutene 

Relevant academic research and scientific papers

Synthesis of Benzo[ b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogues, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.

A novel and versatile synthesis of 1-arylbenzocyclobutenols and 1-arylbenzocyclobutenes

Lithium halogen exchange has been achieved in the substrate 5, in the presence of a carbonyl group, using n-butyllithium.This leads to the first convenient synthesis of 1-arylbenzocyclobutenols (1) in good yields.

A novel and versatile synthesis of 1-aryl-benzocyclobutenols and 1-aryl-benzocyclobutenes

Halogen metal exchange, occurring in presence of electrophilic centres, provides a simple and efficient route to 1-aryl-benzocyclobutenols and benzocyclobutenes.