134454-90-3

Upstream product

• 15190-13-3 (4-methoxy-phenyl)-morpholin-4-yl-acetonitrile 
• 134454-82-3 1-(4-methoxyphenyl)-2-(2'-iodo-4',5'-methylenedioxyphenyl)ethanone 
• 65673-83-8 5-(chloromethyl)-6-iodobenzo[d][1,3]dioxole 
• 134454-86-7 1-(4'-methoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol 

Relevant academic research and scientific papers

A novel and versatile synthesis of 1-arylbenzocyclobutenols and 1-arylbenzocyclobutenes

Lithium halogen exchange has been achieved in the substrate 5, in the presence of a carbonyl group, using n-butyllithium.This leads to the first convenient synthesis of 1-arylbenzocyclobutenols (1) in good yields.

A novel and versatile synthesis of 1-aryl-benzocyclobutenols and 1-aryl-benzocyclobutenes

Halogen metal exchange, occurring in presence of electrophilic centres, provides a simple and efficient route to 1-aryl-benzocyclobutenols and benzocyclobutenes.