134454-88-9

Basic information

• Product Name: 1-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol
• Synonyms: 1-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol
• CAS NO: 134454-88-9
• Molecular Weight: 330.337
• Mol File: 134454-88-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol(134454-88-9)
• EPA Substance Registry System: 1-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-4,5-methylenedioxybenzocyclobuten-1-ol(134454-88-9)

Safety Data

• Hazardous Substances Data: 134454-88-9(Hazardous Substances Data)

Upstream product

• 69048-76-6 6-iodo-1,3-benzodioxole-5-methanol 
• 2139-43-7 5-bromo-6-(1,3-dioxolan-2-yl)benzo[d][1,3]dioxolane 
• 68415-05-4 α-(3,4,5-trimethoxyphenyl)-α-morpholinoacetonitrile 
• 134454-84-5 1-(3,4,5-trimethoxyphenyl)-2-(2'-iodo-4',5'-methylenedioxyphenyl)ethanone 
• 1027284-64-5 5-(1,3-dioxolan-2-yl)-6-iodo-1,3-benzodioxole 
• 65673-83-8 5-(chloromethyl)-6-iodobenzo[d][1,3]dioxole 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 58343-53-6 6-iodopiperonal 
• 1026573-14-7 3-(6-Iodo-benzo[1,3]dioxol-5-yl)-2-morpholin-4-yl-2-(3,4,5-trimethoxy-phenyl)-propionitrile 

Downstream Products

• 134454-92-5 1-(3',4',5'-trimethoxyphenyl)-4,5-methylenedioxybenzocyclobutene 
• 160823-58-5 (5R,6S,7R)-5-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid bis-((S)-methoxycarbonyl-phenyl-methyl) ester 
• 160869-33-0 (5R,5aR,8aR)-5-(3,4,5-Trimethoxy-phenyl)-5,5a,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-6,8-dione 
• 160823-61-0 (5R,6R,7R)-5-(3,4,5-Trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid 
• 160823-59-6 (5R,6R,7R)-5-(3,4,5-Trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6,7-dicarboxylic acid bis-((S)-methoxycarbonyl-phenyl-methyl) ester 
• 477-51-0 deoxypodophyllotoxin 

Relevant articles and documents

An asymmetric synthesis of (-)-deoxypodophyllotoxin

A Diels-Alder cycloaddition between the fumarate of methyl (S)-mandelate (22) and α-hydroxy-α-aryl-o-quinodimethane 21 produces an endo cycloadduct (23) in 58% yield. The preparation of the precursor to o-quinodimethane 21 and the conversion of cycloadduct 23 to optically pure (-)-deoxypodophyllotoxin (1) is described.

A novel and versatile synthesis of 1-aryl-benzocyclobutenols and 1-aryl-benzocyclobutenes

Halogen metal exchange, occurring in presence of electrophilic centres, provides a simple and efficient route to 1-aryl-benzocyclobutenols and benzocyclobutenes.