134456-76-1Relevant articles and documents
o-Trimethylsilylphenyllithium as a synthetic equivalent of o-halophenyllithium
Takahashi, Masaki,Hatano, Ken,Kimura, Mikio,Watanabe, Toshinari,Oriyama, Takeshi,Koga, Gen
, p. 579 - 582 (1994)
The reaction of o-trimethylsilylphenyllithium with carbonyl compounds and subsequent halogenodesilylation with ICl afforded o-iodophenylcarbinols in good yields, showing the usefulness of o-trimethylsilylphenyllithium as a synthetic equivalent of o-iodophenyl anion. The reaction via a protected o-trimethylsilylphenylcarbinol is also shown.
Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones
Liu, Wenbo,Guo, Jun,Xing, Shipei,Lu, Zhan
supporting information, p. 2532 - 2536 (2020/04/02)
A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.
Nitrogen-Iodine Exchange of Diaryliodonium Salts: Access to Acridine and Carbazole
Wang, Ming,Fan, Qiaoling,Jiang, Xuefeng
supporting information, p. 216 - 219 (2018/01/17)
A nitrogen-iodine exchange protocol of diaryliodonium salts with sodium azide salt is developed for general construction of significant functional acridines and carbazoles, in which introduction of nitrogen at a late stage was successfully established avoiding heteroatom incompatibility. Inorganic sodium azide served as the sole nitrogen atom source in this transformation. The diversiform functional acridines and carbazoles were comprehensively achieved through annulated diaryliodonium salts, respectively. Notably, Acridine orange (a fluorescent indicator for cell lysosomal dye) and Carprofen (a nonsteroidal anti-inflammatory drug) were efficiently established through this protocol.
