25187-00-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Iodobenzophenone is used as a pharmaceutical intermediate for the synthesis of various medications. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Organic Synthesis:
As a reagent in organic synthesis, 2-Iodobenzophenone is employed in various chemical reactions to produce a wide range of organic compounds. Its versatility in organic chemistry makes it an essential tool for researchers and chemists in the development of new chemical entities.
Used in Specialty Chemicals Production:
2-Iodobenzophenone is utilized in the production of specialty chemicals, which are high-value chemicals used in specific applications due to their unique properties. Its role in this industry highlights its importance in creating specialized products for various markets.
Used in Agrochemicals Synthesis:
As a building block in the synthesis of agrochemicals, 2-Iodobenzophenone contributes to the development of pesticides, herbicides, and other agricultural chemicals. Its presence in this field underscores its significance in enhancing crop protection and agricultural productivity.
It is crucial to handle 2-Iodobenzophenone with care and adhere to all safety guidelines when working with 2-IODOBENZOPHENONE, given its potential hazards. Proper handling and safety measures ensure the safe and effective use of this valuable chemical in various industries.

InChI:InChI=1/C13H9IO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9H

Upstream product

• 609-67-6 2-Iodobenzoyl chloride 
• 71-43-2 benzene 
• 98-88-4 benzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 
• 108-86-1 bromobenzene 
• 133776-41-7 anthranilic acid N-methoxy-N-methylamide 
• 85-52-9 2-Benzoylbenzoic acid 
• 134456-76-1 (2-iodophenyl)(phenyl)methanol 
• 591-50-4 iodobenzene 
• 26260-02-6 2-iodobenzaldehyde 
• 35444-93-0 ortho-benzyliodobenzene 
• 5159-41-1 2-iodobenzyl alcohol 

Downstream Products

• 91-01-0 1,1-Diphenylmethanol 
• 99763-20-9 2-iodobenzophenone oxime 
• 7007-67-2 3-phenyl-1,2-benzisoxazole 
• 76049-56-4 1-(2-benzoylphenyl)-3-phthalimidopropyne 
• 73183-53-6 2-(Phenothiazin-10-yl)benzophenon 
• 73183-87-6 10-(2-Benzoylphenyl)-9,10-dihydro-9,9-dimethylacridin 
• 144428-00-2 2-(2-iodophenyl)-2-phenyloxirane 
• 119-61-9 benzophenone 
• 486-25-9 9-fluorenone 
• 24018-00-6 2,2'-dibenzoylbiphenyl 
• 99763-20-9 2-iodobenzophenone syn-oxime 
• 143880-87-9 (R)-(2-iodophenyl)(phenyl)methanol 
• 143880-80-2 (S)-(2-iodophenyl)-phenyl-methanol 
• 90072-56-3 C₁₃H₁₁IO₉S₂ 

Relevant academic research and scientific papers

Novel transformation of aryl 2-iodophenyl ketones into 1,3-diarylisoquinolines with (TMS)2NH, styrenes, NIS, and tBuOK

Treatment of aryl 2-iodophenyl ketones with TMS2NH in the presence of Sc(OTf)3 at warming conditions, followed by the reaction with styrenes and NIS gave N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines. Further treatment of N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines with tBuOK in the presence of 1,10-phenanthroline at 120 °C generated 1,3-diarylisoquinolines in moderate yields through SET from tBuOK onto the iodophenyl group to form aryl radicals, their 6-endo-trig cyclization onto the vinyl groups, and aromatization of the cyclized intermediates. The present method is a novel approach for the preparation of the isoquinoline core via two steps from aryl 2-iodophenyl ketones.

A Serendipitous One-Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3-Methyleneisoindolin-1-ones

A direct, one-pot conversion of 2’-haloacetophenones to 3-methyleneisoindolin-1-one scaffolds using CuCN as the sole reagent without the need for moisture-free or anaerobic conditions is reported. This serendipitously discovered transformation with a broa

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Rapid construction of cyclopenta[: B] naphthalene frameworks from propargylic alcohol tethered methylenecyclopropanes

We have developed a new synthetic methodology for the rapid construction of cyclopenta[b]naphthalene frameworks from the reaction of propargylic alcohol tethered methylenecyclopropanes with mesyl chloride in the presence of triethylamine through cascade cyclization. The reaction can be performed under mild conditions without the use of transition metals, affording the target products in moderate to good yields, and this cyclization reaction process can be scaled up to a gram-scale synthesis.

Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones

A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.

Fluorinations of unsymmetrical diaryliodonium salts containing: Ortho -sidearms; Influence of sidearm on selectivity

Activated aromatics were reacted with two different fluoroidoane reagents 1 and 2 in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane 1 the unsymmetrical diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alcohol sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane 2. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution

A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.

Lewis or Br?nsted acid-catalysed reaction of propargylic alcohol-tethered alkylidenecyclopropanes with indoles and pyrroles for the preparation of polycyclic compounds tethered with indole or pyrrole motif

We developed a facile synthetic method to access cyclopenta[b]naphthalene derivatives via the Lewis or Br?nsted acid catalysed cascade nucleophilic addition, electronic cyclization, ring-opening rearrangement of propargylic alcohol-tethered alkylidenecyclopropanes with indole and pyrrole derivatives. The reaction exhibited a broad substrate scope and good functional group tolerance under metal-free conditions, affording the desired products in moderate to good yields.