134470-65-8Relevant articles and documents
Synthesis of Isothiocyanates and Unsymmetrical Thioureas with the Bench-Stable Solid Reagent (Me4N)SCF3
Scattolin, Thomas,Klein, Alexander,Schoenebeck, Franziska
supporting information, p. 1831 - 1833 (2017/04/11)
A highly efficient, selective, and rapid transformation of primary amines and diamines to isothiocyanates and cyclic thioureas is disclosed. As opposed to established approaches that employ toxic or volatile electrophilic liquids and require reaction control (i.e., slow addition, cooling), this protocol utilizes the bench-stable, solid reagent (Me4N)SCF3 at room temperature. The method is characterized by operational simplicity, high speed, efficiency, high functional group tolerance, and late-stage applicability. The byproducts are solids, allowing isolation of the target compounds by filtration.
Studies on Reaction of 2-Aminoacetophenone with Thiophosgene
Morgenstern, Olaf,Richter, Peter,Rouvinen, Juha,Maelkoenen, Pentii J.,Vainiotalo, Pirjo,et al.
, p. 1091 - 1097 (2007/10/02)
The reaction of 3- and 4-aminoacetophenone with thiophosgene in a chloroform-water-calcium carbonate mixture at room temperature results in good yields of the related, known isothiocyanates.At first, however, we failed in all our attempts to produce 2-iso
