1344719-01-2

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 702-24-9 4-methoxy-N-methylbenzylamine 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 
• 13114-23-3 4-methoxybenzyl-N-methylimine 

Downstream Products

• 1344719-04-5 2-(N-(4-methoxybenzyl)-N-methylamino)-6-(1-(2,6-difluorophenyl)ethyl)pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

INHIBITORS OF RAF KINASES

Provided herein are heteroaryl inhibitors of receptor tyrosine kinase effector (RAF), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of disease.

A domino microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones

A practical microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones has been developed. This approach is based on a domino Michael addition-cyclocondensation reaction between substituted thioureas/guanidines and acetylenecarboxyla