134472-30-3Relevant academic research and scientific papers
Polymorphic and solvate structures of ethyl ester and carboxylic acid derivatives of WIN 61893 analogue and their stability in solution
Salorinne, Kirsi,Lahtinen, Tanja,H?kkinen, Hannu,Marjom?ki, Varpu
, p. 9001 - 9009 (2015/03/03)
3-Ethyl ester- (1) and 3-carboxylic acid-isoxazole (2) derivatives of an antiviral drug analogue WIN 61893 were synthesized and characterized by X-ray crystallography and NMR spectroscopy. Crystallization experiments afforded two polymorphic structures fo
Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity
Diana,Volkots,Nitz,Bailey,Long,Vescio,Aldous,Pevear,Dutko
, p. 2421 - 2436 (2007/10/02)
A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the MIC80, the concentration which inhibits 80% or 12 of the serotypes tested, was determined. Homologation of the alkyl
1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
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, (2008/06/13)
Compounds of the formula STR1 wherein: Y is alkylene of 3 to 9 carbon atoms; R1 is lower-alkyl, lower-alkoxy-(C1-3 -alkyl), lower-alkoxycarbonyl, cyclopropyl or trifluoromethyl; R2 and R3 independently are hydro
1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
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, (2008/06/13)
Compounds of the formulas STR1 wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms; R1 and R2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; and R8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R8 is hydrogen R' is hydroxy-lower-alkyl, are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
