134485-39-5Relevant academic research and scientific papers
Stereocontrolled synthesis of β-2'-deoxypyrimidine nucleosides via intramolecular glycosylations
Xia, Xiaoyang,Wang, Jianying,Hager, Michael W.,Sisti, Nicholas,Liotta, Dennis C.
, p. 1111 - 1114 (2007/10/03)
A pyrimidine moiety was tethered at the 3'-β-position of D-threo-furanosides. By carefully controlling the reaction conditions, pyrimidine bases can be delivered to the anomeric center to give of β-pyrimidine nucleosides in good yield and with complete stereocontrol.
An efficient synthesis of 3′-fluoro-3′-deoxythymidene (FLT)
Hager, Michael W.,Liotta, Dennis C.
, p. 7083 - 7086 (2007/10/02)
A synthetic route which permits the regioselective introduction of fluoride into an FLT precursor under mild conditions and the subsequent conversion of that intermediate into FLT is reported.
