1345097-48-4

Upstream product

• 56753-76-5 2-isocyanato-3-phenyl-propionic acid methyl ester 
• 100-46-9 benzylamine 
• 51987-73-6 methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate 
• 3173-56-6 benzyl isothiocyanate 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 

Downstream Products

• 1432746-75-2 (R)-methyl 2-(3-benzylureido)-3-phenylpropanoate 
• 125369-25-7 methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate 

Relevant academic research and scientific papers

One-pot synthesis of ureas from Boc-protected amines

A practical one-pot synthesis of ureas is described. Boc-protected amines can be transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride for the in situ generation of an isocyanate, which reacts with an amine. A variety of amines can be employed successfully, leading to high yields of isolated ureas.

TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2

Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof.