56753-76-5

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 503-38-8 trichloromethyl chloroformate 
• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 51987-73-6 methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate 
• 107049-37-6 C₁₇H₁₇NO₄ 

Downstream Products

• 60112-58-5 6-[3-(1-methoxycarbonyl-2-phenyl-ethyl)-ureido]-4-oxo-1,4-dihydro-cinnoline-3-carboxylic acid ethyl ester 
• 1025435-98-6 C₂₇H₂₆ClN₅O₈ 
• 1345097-48-4 methyl 2-(3-benzylureido)-3-phenylpropanoate 
• 1432746-75-2 (R)-methyl 2-(3-benzylureido)-3-phenylpropanoate 
• 125369-25-7 methyl (2S)-2-{[(benzylamino)carbonyl]amino}-3-phenylpropanoate 
• 61299-01-2 C₁₈H₁₈N₂O₅S 
• 61298-64-4 C₁₉H₂₀N₂O₅S 

Relevant academic research and scientific papers

ISOCYANATE PRODUCTION METHOD

An isocyanate production method according to the present invention is a method in which an isocyanate is produced by subjecting a carbamate to thermal decomposition, and includes: a step of preparing a mixture liquid containing the carbamate, an inactive solvent and a polyisocyanate compound; a step of conducting a thermal decomposition reaction of the carbamate by continuously introducing the mixture liquid into a thermal decomposition reactor; a step of collecting a low-boiling decomposition product by continuously extracting the low-boiling decomposition product in a gaseous state from the reactor, the low-boiling decomposition product having a boiling point lower than the polyisocyanate compound; and a step of collecting a high-boiling component by continuously extracting, from the reactor, a liquid phase component which is not collected in a gaseous state at the step of collecting the low-boiling decomposition product.

One-pot synthesis of ureas from Boc-protected amines

A practical one-pot synthesis of ureas is described. Boc-protected amines can be transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride for the in situ generation of an isocyanate, which reacts with an amine. A variety of amines can be employed successfully, leading to high yields of isolated ureas.

Design, synthesis, and in vitro evaluation of potential west nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds

The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have led to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases.

Preparation and use of N-iodopropargyl oxycarbonyl amino acid esters and derivatives as antimicrobial agents

Antimicrobial compounds of the formula STR1 wherein R1 is selected from the group consisting of H, lower (C1 -C4)alkyl, alkyl aryl, CH2 OR, CH2 SR, and CH(CH3)OR; and R, R2, and

Novel hydrazinocarboxamide derivatives and preparation thereof

α-Hydrazinocarboxamide and α-(α'-acylhydrazino)-carboxamide derivatives of formula I STR1 in which R1 and R2 each are lower alkyl or R1 and R2 together with the nitrogen atom to which they are joined form a pipe