134513-92-1Relevant academic research and scientific papers
An improved stereoselective synthesis of 5-acyl-2-amino-4-aryl-3-cyano- 4,5-dihydrothiophenes
Samet, Aleksandr V.,Shestopalov, Anatolij M.,Nesterov, Vladimir N.,Semenov, Victor V.
, p. 623 - 624 (1997)
Sulfonium ylides generated from precursor bromides 2 react readily with arylidenecyanothioacetamides 1 to afford the title compounds with trans- configuration.
Stereoselective synthesis of trans-2,3-disubstituted 5-amino-4-cyano-2,3-dihydrothiophenes
Shestopalov,Bogomolova,Litvinov
, p. 277 - 278 (2007/10/02)
Interaction of 1-(1-adamantylcarbonylmethyl)pyridinium bromide (1) with arylmethylenecyanothioacetamides 2 proceeds stereoselectively with formation of 2-(1-adamantylcarbonyl)-5-amino-3-aryl-4-cyano-2,3-dihydrothiophenes. Dihydrothiophenes were obtained in a good yield by three-component condensation of pyridinium bromide 1, aldehydes and cyanothioacetamide in presence of triethylamine.
