An improved stereoselective synthesis of 5-acyl-2-amino-4-aryl-3-cyano- 4,5-dihydrothiophenes

DOI: 10.1055/s-1997-1396

Source and publish data:

Synthesis p. 623 - 624 (1997)

Update date:2022-08-03

Topics:

Authors:

Samet, Aleksandr V.

Shestopalov, Anatolij M.

Nesterov, Vladimir N.

Semenov, Victor V.

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Article abstract of DOI:10.1055/s-1997-1396

Sulfonium ylides generated from precursor bromides 2 react readily with arylidenecyanothioacetamides 1 to afford the title compounds with trans- configuration.

Full text of DOI:10.1055/s-1997-1396

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Product name:(4R,5R)-5-(Adamantane-1-carbonyl)-2-amino-4-(4-methoxy-phenyl)-4,5-dihydro-thiophene-3-carbonitrile

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