134529-31-0Relevant articles and documents
Synthesis, cytotoxic activity, and tubulin polymerization inhibitory activity of new pyrrol-2(3H)-ones and pyridazin-3(2H)-ones
Abbas, Samar Hafez,Abuo-Rahma, Gamal El-Din A.A.,Abdel-Aziz, Mohamed,Aly, Omar M.,Beshr, Eman A.,Gamal-Eldeen, Amira M.
, p. 46 - 62 (2016/04/05)
A series of new pyrrol-2(3H)-ones 4a-f and pyridazin-3(2H)-ones 7a-f were synthesized and characterized using different spectroscopic tools. Some of the tested compounds revealed moderate activity against 60 cell lines. The E form of the pyrrolones 4 show