1345346-05-5

Upstream product

• 910875-39-7 4-oxo-3-phenylpiperidine hydrochloride 
• 1345345-81-4 1-benzyl-3-phenyl-4-piperidone hydrochloride 
• 1345346-06-6 C₁₈H₁₉BrN₂O 
• 109-90-0 ethyl isocyanate 
• 1384264-55-4 C₂₁H₂₃NO₃ 
• 880135-38-6 tert-butyl (3R,4S)-4-amino-3-phenylpiperidine-1-carboxylate 
• 632352-56-8 (±)-tert-butyl 4-oxo-3-phenylpiperidine-1-carboxylate 
• 446302-83-6 1-N-benzyl-3-phenyl-4-piperidone 

Relevant academic research and scientific papers

Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists

We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified as potent tachykinin NK1 receptor antagonists by structural modification of the 3-benzhydrylpiperidone derivative through high-throughput screening. N-{2-[(3R,4S)-4-({2-Methoxy-5-[5-(trifluoromethyl)- 1Htetrazol-1-yl]benzyl}amino)-3-phenyl-1-piperidinyl]-2-oxoethyl}acetamide ((+)-39) was found to be one of the most potent tachykinin NK1 receptor antagonists with high metabolic stability. Highly efficient asymmetric synthesis of (+)-39 was achieved via dynamic kinetic resolution.